机构：[a]Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology),West China Hospital, Sichuan University, Chengdu, Sichuan Province, People’s Republic of China四川大学华西医院[b]Departments of Health Management Center,West China Hospital, Sichuan University, Chengdu, Sichuan Province, People’s Republic of China四川大学华西医院[c]Departments of Equipment and Material, West China Hospital, Sichuan University, Chengdu, Sichuan Province, People’s Republic of China四川大学华西医院
Metabolic syndrome (MetS) can increase the risk of prostate cancer. Prostate-specific antigen (PSA) is the marker for prostate cancer puncture screening. The aim of our study was to investigate the association between MetS and its components with PSA levels. Data were obtained from 482 943 healthy men who underwent routine health check-ups from January 2010 to December 2017. We used linear regression analysis to evaluate the effects of MetS and its components on PSA levels. To explore the cumulative effect of MetS components, analysis of variance trend analysis was carried out. The PSA levels in the group with MetS were significantly lower than those without MetS (P = 0.001). In the multivariate regression model, age (P < 0.001) and hypertension (P < 0.001) were correlated positively with PSA levels; nevertheless, obesity (P < 0.001), hypertriglyceridemia (P < 0.001), hyperglycemia (P < 0.001), and low high-density lipoprotein cholesterol level (P < 0.001) had a negative correlation. In addition, after adjustment for age, increasing sums of positive MetS components were associated with a linear decrease in PSA levels (P<0.001). In conclusion, MetS, obesity, hypertriglyceridemia, hyperglycemia, and low high-density lipoprotein cholesterol levels are associated with decreased PSA levels. For patients with PSA levels at the critical value of prostate puncture, the effect of these diseases in reducing PSA levels should be taken into account.
基金：
This study was funded by the National Key R&D
Program of China (grant nos 2017YFC0907504 and
2017YFC0907501) and the Health and Family Planning
Commission of Sichuan Province (grant nos 17PJ056,
16PJ35, and ChuanGanYan2017-119).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类|4 区医学
小类|4 区肿瘤学
最新[2023]版：
大类|4 区医学
小类|4 区肿瘤学
第一作者：
第一作者机构：[a]Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology),West China Hospital, Sichuan University, Chengdu, Sichuan Province, People’s Republic of China
共同第一作者：
通讯作者：
通讯机构：[b]Departments of Health Management Center,West China Hospital, Sichuan University, Chengdu, Sichuan Province, People’s Republic of China[*1]Department of Health Management Center, West China Hospital, Sichuan University, Guo Xue Xiang 37, Chengdu 610041, Sichuan Province, People’s Republic of China
推荐引用方式(GB/T 7714)：
Xiaoshuai Gao,Ting Bao,Hanwei Yang,et al.The association of metabolic syndrome and its components with serum prostate-specific antigen levels.[J].European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP).2020,29(1):36-41.doi:10.1097/CEJ.0000000000000508.
APA：
Xiaoshuai Gao,Ting Bao,Hanwei Yang,Yali Lei,Xianwen Jiang...&Huairong Tang.(2020).The association of metabolic syndrome and its components with serum prostate-specific antigen levels..European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP),29,(1)
MLA：
Xiaoshuai Gao,et al."The association of metabolic syndrome and its components with serum prostate-specific antigen levels.".European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 29..1(2020):36-41
