Aim: To observe the effects of combined interventions of oncology, psychology and social medicine on life quality of patients with nasopharyngeal carcinoma. Methods: Seventy-two patients with nasopharyngeal carcinoma, who were identified in West China Hospital of Sichuan University and Sichuan Provincial Cancer Hospital from January 2001 to July 2002 were randomly divided into intervention group (n=35) and control group (n=37). The health intervention was performed with mass anti-cancer method under systematic anti-cancer direction of specialists including multiple aspects such as body function, mental state, recovery of role in society and family etc. with the an interventional duration of 2 years. Patients in the control group were in a spontaneous convalescence. Double-blind investigation was conducted on patients by investigators. The scale was composed of 6 measuring dimension and 43 items including general healthy body function, mental state, function of society and family, symptoms and side effects, self-evaluated quality of life and special side effects. Differences in quality of life between two groups were compared with analysis of covariance. Patients in the control group were investigated with questionnaires twice respectively in grouping and the follow-up of 2 years later. Results: Treatment and questionnaire were conducted in patients of two groups and all subjects entered the final analysis. 1Score of each dimension and total score of patients in the intervention group were higher than those before intervention, (P < 0.05 or P < 0.01). Score of each dimension and total score in follow-up of the control group were higher than those in grouping (P < 0.05 or P < 0.01).2Scores of mental state, special side effects, self-evaluation and differences of total score in patients of intervention group were higher than those in the control group and differences were remarkable (P < 0.05 or P < 0.01). 3After the disproportion factors was controlled, scores of mental state, special side effects, self-evaluation and differences of total score in patients of intervention group were still higher than those in the control group, and differences were marked (P < 0.05 or P < 0.01), which showed that quality of life in patients of intervention group were significantly increased in these dimensions. Conclusion: Combined intervention of multiple subjects facilitate the elevation of life quality of patients with nasopharyngeal carcinoma and can significantly improve mental status, special symptoms and side effects and somatic function of patients. But its remote effects on functions of society and family needs further observation.