机构：[1]State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, Guangdong, P. R. China.[2]Department of Medical Imaging and Interventional Radiology, Sun Yat-sen University Cancer Center, Guangzhou 510060, Guangdong, P. R. China.[3]Zhongshan School of Medical, Sun Yat-sen University, Guangzhou 510080, Guangdong, P. R. China.[4]Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, Guangdong, P. R. China.[5]Department of Medical Oncology, Sichuan Cancer Hospital and Institute, Second People’s Hospital of Sichuan Province, Chengdu 610041, Sichuan, P. R. China.四川省人民医院四川省肿瘤医院
Background: Although the prognostic impact of body mass index(BMI) in patients with non?metastatic naso?pharyngeal carcinoma(NPC) had been extensively studied, its effect among metastatic NPC patients remains unknown. The purpose of this study was to evaluate the prognostic effect of BMI in patients with metastatic NPC.Methods: We retrospectively studied 819 patients who were diagnosed with distant metastasis from NPC and received treatment between 1998 and 2007. The patients were divided into three subgroups according to the World Health Organization classifications for Asian populations: underweight(BMI (18.5 kg/m2), normal weight(BMI 18.5–22.9 kg/m2), and overweight/obese(BMI ≥23.0 kg/m2). The associations of BMI with overall survival(OS) and progression?free survival(PFS) were determined by Cox regression analysis.Results: Of the 819 patients, 168(20.5%) were underweight, 431(52.6%) were normal weight, and 220(26.9%) were overweight/obese. Multivariate analysis adjusted for covariates showed that overweight/obese patients had a longer OS than underweight patients [hazard ratio(HR), 0.64; 95% confidence interval(CI), 0.49–0.84] and normal weight patients(HR, 0.72; 95% CI, 0.57–0.90); no significant difference in PFS was observed among these three groups(P = 0.407). Moreover, in stratified analysis, no statistically significant differences in the effect of overweight/obese status among different subgroups were observed.Conclusion: For patients with metastatic NPC, overweight/obese status was associated with longer OS but not longer PFS compared with underweight or normal weight status.
基金：
National High Technology Research and Development Program of China (863 Program)National High Technology Research and Development Program of China [2012AA022701]
第一作者机构：[1]State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, Guangdong, P. R. China.[2]Department of Medical Imaging and Interventional Radiology, Sun Yat-sen University Cancer Center, Guangzhou 510060, Guangdong, P. R. China.
共同第一作者：
通讯作者：
通讯机构：[1]State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, Guangdong, P. R. China.[2]Department of Medical Imaging and Interventional Radiology, Sun Yat-sen University Cancer Center, Guangzhou 510060, Guangdong, P. R. China.
推荐引用方式(GB/T 7714)：
Wang Li,Lu‑Jun Shen,Tao Chen,等.Overweight/obese status associates with favorable outcome in patients with metastatic nasopharyngeal carcinoma: a 10-year retrospective study[J].癌症(英文版).2016,(9):476-484.
