CT-guided radiofrequency ablation after with transarterial chemoembolization in treating unresectable hepatocellular carcinoma with long overall survival improvement
机构:[1]Minimally Invasive Interventional Division, Medical Imaging Center, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in Southern China, Guang Zhou, Guang Dong, China[2]Medical Oncology, Sichuan Cancer Hospital & Institute, The Second People’s Hospital of Sichuan Province, Chen Du, China四川省人民医院四川省肿瘤医院
Purpose: To assess the time to disease progression (TTP), long-term survival benefit and safety of patients with unresectable hepatocellular carcinoma (HCC) treated with computed tomography (CT)-guided radiofrequency ablation (RFA) with transarterial chemoembolization chemoembolization (TACE). Methods: This study was approved by the institutional review board. We reviewed the records of patients with intermediate and advanced HCC treated with CT-guided RFA with TACE between January 2000 and December 2009. Median TTP, overall survival (OS) and hepatic function were analyzed with the Kaplan-Meier method and log-rank tests. Results: One hundred and twenty-two patients (112 men and 10 women, mean age 53 years, range 18-86 years) were included in the study. The median follow-up time was 42 months (range 6-89 months), TTP was 6.8 months, the median OS was 31 months, and the 1-, 3-, and 5-year OS were 88.5%, 41.0%, and 10.7%. The results of the univariate analysis revealed that intrahepatic lesion, AJCC stage, and Child-Pugh stage were predictors of OS (P < 0.01). In the multivariate analysis, the AJCC stage system showed a statistically significant difference for prognosis. Procedure-related death was 0.21% (1/470) within 1 month, and a statistical difference was found between the TACE and RFA of liver decompensation and Child-Pugh stage (P < 0.05). Conclusions: The survival probabilities of OS increased with CT-guided RFA with TACE, as observed in randomized studies from Europe and Asia. The longest TTP was observed for the intermediate stage HCC. The procedures were well tolerated with acceptable minor and major complications in unresectable HCC patients. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
基金:
Ministry of Public Health of China, for major national projects in medical, scientific, and technological innovation [2008ZX09312-002]
第一作者机构:[1]Minimally Invasive Interventional Division, Medical Imaging Center, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in Southern China, Guang Zhou, Guang Dong, China[*1]Minimally Invasive Interventional Division, Medical Imaging Center, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in Southern China, 651 Dongfeng East Avenue, Guangzhou 510060, PR China
通讯作者:
通讯机构:[1]Minimally Invasive Interventional Division, Medical Imaging Center, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in Southern China, Guang Zhou, Guang Dong, China[*1]Minimally Invasive Interventional Division, Medical Imaging Center, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in Southern China, 651 Dongfeng East Avenue, Guangzhou 510060, PR China
推荐引用方式(GB/T 7714):
Zhao Ming,Wang Jian-peng,Pan Chang-chuan,et al.CT-guided radiofrequency ablation after with transarterial chemoembolization in treating unresectable hepatocellular carcinoma with long overall survival improvement[J].EUROPEAN JOURNAL OF RADIOLOGY.2012,81(10):2717-2725.doi:10.1016/j.ejrad.2011.10.023.
APA:
Zhao, Ming,Wang, Jian-peng,Pan, Chang-chuan,Li, Wang,Huang, Zi-lin...&Wu, Pei-hong.(2012).CT-guided radiofrequency ablation after with transarterial chemoembolization in treating unresectable hepatocellular carcinoma with long overall survival improvement.EUROPEAN JOURNAL OF RADIOLOGY,81,(10)
MLA:
Zhao, Ming,et al."CT-guided radiofrequency ablation after with transarterial chemoembolization in treating unresectable hepatocellular carcinoma with long overall survival improvement".EUROPEAN JOURNAL OF RADIOLOGY 81..10(2012):2717-2725