机构：[1]State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 55, Section 3 Renmin Road South, Chengdu 610041, Sichuan Province, China[2]Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu 610041, Sichuan Province, China外科中心头颈外科中心四川省肿瘤医院头颈外科[3]Department of Radiation Oncology, Chengdu Third Pepole Hospital, Chengdu 610031, Sichuan Province, China[4]Department of Oral Pathology, West China College of Stomatology, Sichuan University, No. 55, Section 3 Renmin Road South, Chengdu 610041, Sichuan Province, China[5]Department of Oral and Maxillary Surgery, The Affiliated Hospital of Guiyang Medical College, Guiyang 550004, Guizhou Province, China
This study sought to determine the expression of angiopoietin-2 (Ang-2) and vascular endothelial cell growth factor (VEGF) in oral squamous cell carcinoma (OSCC) and assess their correlations with tumor progression, angiogenesis, vessel maturation, and clinical survival. Tumor tissue from 102 OSCC patients, adjacent noncancerous oral tissue from 79 OSCC patients, and normal oral mucosa from 35 control patients were examined for Ang-2 and VEGF expression using conventional immunohistochemistry. Microvessel density (MVD) and vessel maturation index (VMI) were assessed by double-label immunohistochemistry staining using anti-CD34 and anti-alpha-smooth muscle actin, respectively. Although the proportion of OSCC samples positive for Ang-2 or VEGF expression was significantly higher than that observed in the adjacent noncancerous tissue and normal oral mucosa (P < 0.001), neither Ang-2 nor VEGF expression was associated with the clinicopathological parameters analyzed in OSCC patients. However, MVD and VMI were significantly associated with the expression of Ang-2 (P = 0.001 and P = 0.014, respectively); VEGF expression was associated MVD (P = 0.004). The MVD of OSCC tissues expressing both Ang-2 and VEGF was significantly higher than observed in the double-negative samples (P < 0.05). Multivariate regression and Kaplan-Meier analyses revealed that Ang-2 was negatively associated with the overall survival of OSCC patients. Expression of Ang-2 was associated with angiogenesis and vessel maturation in OSCC. Further studies will evaluate the prognostic value of determining Ang-2 expression in OSCC.
基金：
Sichuan Provincial Bureau of Health [080390, 100572]; Sichuan Provincial Science and Technology Department [2009JY0093, 2010FZ0099]
第一作者机构：[1]State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 55, Section 3 Renmin Road South, Chengdu 610041, Sichuan Province, China[2]Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu 610041, Sichuan Province, China
共同第一作者：
通讯作者：
通讯机构：[1]State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 55, Section 3 Renmin Road South, Chengdu 610041, Sichuan Province, China[4]Department of Oral Pathology, West China College of Stomatology, Sichuan University, No. 55, Section 3 Renmin Road South, Chengdu 610041, Sichuan Province, China
推荐引用方式(GB/T 7714)：
Chao Li,Chang-jin Sun,Jin-chuan Fan,et al.Angiopoietin-2 expression is correlated with angiogenesis and overall survival in oral squamous cell carcinoma[J].MEDICAL ONCOLOGY.2013,30(2):doi:10.1007/s12032-013-0571-2.
APA：
Chao Li,Chang-jin Sun,Jin-chuan Fan,Ning Geng,Chun-hua Li...&Yu Chen.(2013).Angiopoietin-2 expression is correlated with angiogenesis and overall survival in oral squamous cell carcinoma.MEDICAL ONCOLOGY,30,(2)
MLA：
Chao Li,et al."Angiopoietin-2 expression is correlated with angiogenesis and overall survival in oral squamous cell carcinoma".MEDICAL ONCOLOGY 30..2(2013)
