机构：[1]Department of Radiation Oncology, Chengdu Third People’s Hospital, Sichuan, 610041, China[2]Department of Head and Neck Surgery Oncology, Sichuan Cancer Hospital, Sichuan, 610041, China外科中心头颈外科中心四川省肿瘤医院头颈外科[3]Department of Radiation Oncology, Shandong Cancer Hospital, No. 8 Zhenyunling Road, Chengdu, Sichuan, 610202, China[4]Department of Radiation Oncology, Sichuan Cancer Hospital, Sichuan, 610041, China四川省肿瘤医院[5]Department of Radiology, Civil Aviation Medical Center, Chengdu, Sichuan, 610041, China
The aim of this study was to evaluate the oxygen partial pressure of the rabbit model of the VX2 tumor using a 64-slice perfusion CT and to compare the results with that obtained using the oxygen microelectrode method. Perfusion CT was performed for 45 successfully constructed rabbit models of a VX2 brain tumor. The perfusion values of the brain tumor region of interest, the blood volume (BV), the time to peak (TTP) and the peak enhancement intensity (PEI) were measured. The results were compared with the partial pressure of oxygen (PO2) of that region of interest obtained using the oxygen microelectrode method. The perfusion values of the brain tumor region of interest in 45 successfully constructed rabbit models of a VX2 brain tumor ranged from 1.3-127.0 (average, 21.1 +/- 26.7 ml/min/ml); BV ranged from 1.2-53.5 ml/100g (average, 22.2 +/- 13.7 ml/100g); PEI ranged from 8.7-124.6 HU (average, 43.5 +/- 28.7 HU); and TTP ranged from 8.2-62.3 s (average, 38.8 +/- 14.8 s). The PO2 in the corresponding region ranged from 0.14-47 mmHg (average, 16 +/- 14.8 mmHg). The perfusion CT positively correlated with the tumor PO2, which can be used for evaluating the tumor hypoxia in clinical practice.
基金：
National Natural Science Foundation of China (NSFC)National Natural Science Foundation of China [c30670618]; Science Technology Funds for Young Scholars of Sichuan Province [09ZQ026-065]
基金编号：c3067061809ZQ026-065
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类|4 区医学
小类|4 区生物学4 区核医学
最新[2023]版：
大类|4 区医学
小类|3 区生物学4 区肿瘤学4 区核医学
JCR分区：
出版当年[2014]版：
Q2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ2BIOLOGY
最新[2023]版：
Q2BIOLOGYQ3ONCOLOGYQ3RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
第一作者机构：[1]Department of Radiation Oncology, Chengdu Third People’s Hospital, Sichuan, 610041, China[*1]Department of Radiation Oncology, Chengdu Third People’s Hospital, No. 82 Qinglong Street, Chengdu, Sichuan, 610031, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Radiation Oncology, Chengdu Third People’s Hospital, Sichuan, 610041, China[*1]Department of Radiation Oncology, Chengdu Third People’s Hospital, No. 82 Qinglong Street, Chengdu, Sichuan, 610031, China
推荐引用方式(GB/T 7714)：
Sun Chang-Jin,Li Chao,Lv Hai-Bo,et al.Comparing CT perfusion with oxygen partial pressure in a rabbit VX2 soft-tissue tumor model[J].JOURNAL OF RADIATION RESEARCH.2014,55(1):183-190.doi:10.1093/jrr/rrt092.
APA：
Sun, Chang-Jin,Li, Chao,Lv, Hai-Bo,Zhao, Cong,Yu, Jin-Ming...&Lang, Jin-Yi.(2014).Comparing CT perfusion with oxygen partial pressure in a rabbit VX2 soft-tissue tumor model.JOURNAL OF RADIATION RESEARCH,55,(1)
MLA：
Sun, Chang-Jin,et al."Comparing CT perfusion with oxygen partial pressure in a rabbit VX2 soft-tissue tumor model".JOURNAL OF RADIATION RESEARCH 55..1(2014):183-190
