机构：[1]Navy General Hospital, Beijing, China[2]Shanghai Children’s Medical Center, Shanghai, China,[3]Beijing Children’s Hospital, Beijing, China,首都医科大学附属北京儿童医院[4]Second Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China,中山大学附属第二医院[5]Prince of Wales Hospital, Hong Kong, China,[6]West China Second University Hospital of Sichuan University, Chengdu, China,[7]Guangzhou Women and Children Medical Center, Guangzhou, China,[8]Beijing Tongren Hospital, Beijing, China,首都医科大学附属同仁医院[9]Children’s Hospital of Chongqing Medical University, Chongqing, China,[10]Zhe Jiang University School of Medicine Children Hospital, Hangzhou, China,[11]Soochow University Affiliated Children’s Hospital, Suzhou, China,[12]Capital Institute of Pediatics, Beijing, China,[13]Wuhan Union Hospital, Wuhan, China华中科技大学同济医学院附属协和医院
The success of treating a wide variety of pediatric diseases with HSCT, hematologic malignancies in particular, has resulted in an increased number of long-term survivors. This study is the first large-scale, multicentre report that describes the evolution of pediatric HSCTs in China during the period of 1998-2012. Of all 1052 patients, 266 cases were treated with autologous HSCs and 786 used allogeneic HSCs. The disease indications for HSCTs mainly included leukemias, lymphoma, solid tumors, and non-malignant disorders. The total number of HSCTs, especially unrelated donor transplants, appeared to be increasing year by year. For patients with neuroblastoma, the therapeutic efficacy seemed to be poor, with a five-yr OS and DFS rate of 34.5 +/- 14.3% and 20.7 +/- 9.6%, respectively. In contrast, the survival of patients with SAA was prominently improved, and their five-yr OS and DFS rates were 82.8 +/- 4% and 80.7 +/- 4.1%, respectively. Patients who received cord blood transplants had a lower incidence of acute GVHD than that of PB and/or BM transplants from unrelated donors. This report offers us a valuable resource for evaluating the changes in HSCTs in China over the past 14yr.
通讯机构：[1]Navy General Hospital, Beijing, China[*1]Department of Pediatrics, Navy General Hospital, No. 6, Fucheng Road, Beijing 100048, China
推荐引用方式(GB/T 7714)：
Hong Du,Jing Chen,Maoquan Qin,et al.Pediatric hematopoietic stem cell transplantation in China: Data and trends during 1998-2012[J].PEDIATRIC TRANSPLANTATION.2015,19(5):563-570.doi:10.1111/petr.12525.
APA：
Hong Du,Jing Chen,Maoquan Qin,Jianpei Fang,Zhiguang Li...&Zuo Luan.(2015).Pediatric hematopoietic stem cell transplantation in China: Data and trends during 1998-2012.PEDIATRIC TRANSPLANTATION,19,(5)
MLA：
Hong Du,et al."Pediatric hematopoietic stem cell transplantation in China: Data and trends during 1998-2012".PEDIATRIC TRANSPLANTATION 19..5(2015):563-570
