机构：[1]Departments of Radiation Oncology,Sichuan Cancer Hospital and Institution, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China四川省人民医院四川省肿瘤医院[2]Departments of Intensive Care Unit, Sichuan Cancer Hospital and Institution, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China四川省人民医院四川省肿瘤医院[3]Departments of GCP Center,Sichuan Cancer Hospital and Institution, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China四川省人民医院四川省肿瘤医院[4]Departments of Head and Neck Oncology, Sichuan Cancer Hospital and Institution, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China四川省人民医院四川省肿瘤医院[5]Sichuan Center for Disease Control and Prevention, Chengdu, China
The entire body of a patient with cancer is exposed to low-dose levels of radiation (mGy) during radiation therapy. The safety and biological impact of such exposure to low-dose radiation on the human body are largely unknown. The fingernail is a highly proliferative tissue, and its growth can be monitored during radiation treatment to analyze early effects of low-dose radiation. The fingernails of 30 patients who received external beam radiotherapy (EBRT) were used in this study to investigate the change in nail growth during fractionated radiotherapy. Lead shields were applied to some fingers to create dose variance within individual patients. The absorbed dose was measured, and the relationship between the dose and change in nail growth rate was analyzed. Other factors, including serum albumin, hemoglobin level, body weight index, age, gender and chemotherapy, were also subjected to multivariate analysis. Fingernails from patients received an average of 0.96 mGy per treatment fraction. We observed a surprising decline in fingernail growth rate during radiotherapy, which was more prominent in the nonshielded fingernails with a relatively high-absorbed dose. Such growth delay could be observed as early as one week postirradiation and lasted the entire treatment course. Using fingernail growth as a novel marker for radioresponse, the current study showed that exposure to very low-dose ionizing radiation has previously unrecognized early effects on human tissue. (C) 2017 by Radiation Research Society
基金：
Sichuan Provincial Fund for Applied Science [2014JY0023]
基金编号：2014JY0023
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区医学
小类|3 区生物学3 区生物物理3 区核医学
最新[2023]版：
大类|3 区医学
小类|2 区生物物理3 区生物学3 区核医学
JCR分区：
出版当年[2017]版：
Q2BIOLOGYQ2BIOPHYSICSQ2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版：
Q2BIOLOGYQ2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ3BIOPHYSICS
第一作者机构：[1]Departments of Radiation Oncology,Sichuan Cancer Hospital and Institution, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
通讯作者：
通讯机构：[4]Departments of Head and Neck Oncology, Sichuan Cancer Hospital and Institution, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China[*1]Sichuan Cancer Hospital, Department of Head and Neck Surgery, 55 Section 4, South Renmin Road, Chengdu, Sichuan 610041, China
推荐引用方式(GB/T 7714)：
Zhang Shichuan,Peng Huan,He Ling,et al.Response of Fingernail Growth to Out-of-Field Low-Dose X ray in Cancer Patients Receiving Radiotherapy[J].RADIATION RESEARCH.2017,187(6):682-688.doi:10.1667/RR14597.1.
APA：
Zhang, Shichuan,Peng, Huan,He, Ling,Zhang, Xudong,Gao, Yiying...&Fan, Jinchuan.(2017).Response of Fingernail Growth to Out-of-Field Low-Dose X ray in Cancer Patients Receiving Radiotherapy.RADIATION RESEARCH,187,(6)
MLA：
Zhang, Shichuan,et al."Response of Fingernail Growth to Out-of-Field Low-Dose X ray in Cancer Patients Receiving Radiotherapy".RADIATION RESEARCH 187..6(2017):682-688
