机构：[1]Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China. 四川大学华西医院[2]Department of Medical Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China四川省人民医院四川省肿瘤医院
Visceral pleural invasion (VPI) has been known to be an adverse prognostic factor in non-small cell lung cancer (NSCLC). However, the prognostic significance of extent of VPI (PL0, PL1 and PL2) remains controversial. We conduct a meta-analysis to summarize available evidence on this topic. PubMed, EMBASE, OVID and The Cochrane Library were searched for published studies from inception to May 9, 2016. A total of 16 studies were included in meta-analysis. Our results showed that patients with PL1 or PL2 had poorer overall survival compared with PL0 (HR = 1.555, 95% CI 1.399, 1.730; HR = 2.447, 95% CI 1.913, 3.130) and patients with PL2 had even poorer overall survival than PL1 (HR = 1.287, 95% CI 1.114, 1.487). Patients with PL1 or PL2 had lower 5-year survival rate than PL0 patients (OR = 0.515, 95% CI 0.415, 0.640; OR = 0.441, 95% CI 0.336, 0.579) and patients with PL2 had even lower 5-year survival rate than PL1 (OR = 0.706, 95% CI 0.545, 0.915). In conclusion, extent of VPI impacts the prognosis of resected NSCLC and VPI should be categorized as PL1 and PL2 in the terms of clinical practice and trials.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81572288]; National Key Technology R&D Program of ChinaNational Key Technology R&D Program; key Innovation Project of Intergovernmental International Science and Technology Cooperation [2016YEE0103400]
第一作者机构：[1]Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China. [2]Department of Medical Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
通讯作者：
推荐引用方式(GB/T 7714)：
Wang Ting,Zhou Chengya,Zhou Qinghua.Extent of Visceral Pleural Invasion Affects Prognosis of Resected Non-small Cell Lung Cancer: A meta-analysis[J].SCIENTIFIC REPORTS.2017,7:doi:10.1038/s41598-017-01845-7.
APA：
Wang, Ting,Zhou, Chengya&Zhou, Qinghua.(2017).Extent of Visceral Pleural Invasion Affects Prognosis of Resected Non-small Cell Lung Cancer: A meta-analysis.SCIENTIFIC REPORTS,7,
MLA：
Wang, Ting,et al."Extent of Visceral Pleural Invasion Affects Prognosis of Resected Non-small Cell Lung Cancer: A meta-analysis".SCIENTIFIC REPORTS 7.(2017)
