机构：[1]West China Medical Center, Sichuan University, Chengdu, China四川大学华西医院[2]West China College of Stomatology, Sichuan University, Chengdu, China[3]College of Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology, Shenyang, China[4]Pathology Department, Sichuan Cancer Hospital, Chengdu, China四川省肿瘤医院[5]School of Basic Medicine, Xinjiang Medical University, Urumqi, China[6]School of Pharmacy, Zunyi Medical University, Zunyi, China[7]Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, China四川大学华西医院[8]West China School of Preclinical and Forensic Medicine, Sichuan University, No. 17, 3rd Section, Renmin Nanlu Road, Chengdu, Sichuan 610041, China
Magnetic-fluorescent nanoparticles have a tremendous potential in biology. As the benefits of these materials gained recognition, increasing attention has been given to the conjugation of magnetic-fluorescent nanoparticles with targeting ligands. The magnetic and fluorescent properties of nanoparticles offer several functionalities, including imaging, separation, and visualization, while the presence of a targeting ligand allows for selective cell and tissue targeting. In this review, methods for the synthesis of targeted magnetic-fluorescent nanoparticles are explored, and recent applications of these nanocomposites to the detection and separation of biomolecules, fluorescent and magnetic resonance imaging, and cancer diagnosis and treatment will be summarized. As these materials are further optimized, targeted magnetic-fluorescent nanoparticles hold great promise for the diagnosis and treatment of some diseases.
基金：
National Natural Science
Foundation of China (Grant No. 11262020) and the Foundation of
Sichuan Provincial Science and Technology Program (grant Nos.
2016SZ0020, 2014FZ0074, and 2014SZ0002-15).
第一作者机构：[1]West China Medical Center, Sichuan University, Chengdu, China[2]West China College of Stomatology, Sichuan University, Chengdu, China
共同第一作者：
通讯作者：
通讯机构：[1]West China Medical Center, Sichuan University, Chengdu, China[8]West China School of Preclinical and Forensic Medicine, Sichuan University, No. 17, 3rd Section, Renmin Nanlu Road, Chengdu, Sichuan 610041, China
推荐引用方式(GB/T 7714)：
Xia Hui,Tong Ruijie,Song Yanling,et al.Synthesis and bio-applications of targeted magnetic-fluorescent composite nanoparticles[J].JOURNAL OF NANOPARTICLE RESEARCH.2017,19(4):doi:10.1007/s11051-017-3833-7.
APA：
Xia, Hui,Tong, Ruijie,Song, Yanling,Xiong, Fang,Li, Jiman...&Wu, Jiang.(2017).Synthesis and bio-applications of targeted magnetic-fluorescent composite nanoparticles.JOURNAL OF NANOPARTICLE RESEARCH,19,(4)
MLA：
Xia, Hui,et al."Synthesis and bio-applications of targeted magnetic-fluorescent composite nanoparticles".JOURNAL OF NANOPARTICLE RESEARCH 19..4(2017)
