机构：[1]Department of Medical Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science & Technology of China, Chengdu, 610041, Sichuan, PR China四川省肿瘤医院[2]Department of Cancer Emergency, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science & Technology of China, Chengdu, 610041, Sichuan, PR China四川省肿瘤医院
Aim: To study the expression profile of NFIX, its prognostic value and the mechanism of its dysregulation in lung adenocarcinoma (LUAD). Patients & materials: A retrospective study was performed by using data from the Cancer Genome Atlas and the Human Protein Atlas. Results: High NFIX RNA expression was an independent prognostic factor of favorable overall survival (HR: 0.687, 95% CI: 0.496-0.951; p=0.024) and recurrence-free survival (HR: 0.700, 95% CI: 0.493-0.994, p=0.046) in LUAD, but not in lung squamous cell carcinoma. NFIX DNA hypermethylation was associated with significantly decreased NFIX expression and shorter overall survival and recurrence-free survival in LUAD. Conclusion:NFIX downregulation might independently predict poor prognosis in LUAD. DNA hypermethylation might be an important cause of the downregulation.
第一作者机构：[1]Department of Medical Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science & Technology of China, Chengdu, 610041, Sichuan, PR China
通讯作者：
推荐引用方式(GB/T 7714)：
Ge Jun,Dong Hang,Yang Ye,et al.NFIX downregulation independently predicts poor prognosis in lung adenocarcinoma, but not in squamous cell carcinoma[J].FUTURE ONCOLOGY.2018,14(30):3135-3144.doi:10.2217/fon-2018-0164.
APA：
Ge, Jun,Dong, Hang,Yang, Ye,Liu, Bin,Zheng, Min...&Li, Juan.(2018).NFIX downregulation independently predicts poor prognosis in lung adenocarcinoma, but not in squamous cell carcinoma.FUTURE ONCOLOGY,14,(30)
MLA：
Ge, Jun,et al."NFIX downregulation independently predicts poor prognosis in lung adenocarcinoma, but not in squamous cell carcinoma".FUTURE ONCOLOGY 14..30(2018):3135-3144
