机构:[1]Department of Nephrology, The First Afliated Hospital of Nanjing Medical University, Nanjing, 210029, China.[2]Intensive Care Unit, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610041, China.四川省人民医院四川省肿瘤医院[3]Department of Information, The First Afliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Acute kidney injury (AKI) is a common disease, but diagnosis is usually delayed or missed in hospitalized patients. The aim of this study was to investigate the impact of under-recognition of AKI (beyond 3 days after AKI onset) on short-time prognosis. Of 785 patients with under-recognition of AKI and 616 patients with timely-recognition of AKI were propensity matched in a 1:1 ratio. The two groups, with a total of 482 matched patients (241:241), were comparable in baseline covariates. Under-recognition of AKI was not associated with 30-day all-cause mortality in the logistic regression model with covariate adjustment (OR = 1.01, 95% CI = 0.62-1.64, p = 0.967). Sensitivity analyses and subgroup analyses also proved the association. There were also no significant differences in causes of 30-day mortality, in-hospital mortality, recovery of renal function at discharge, length of hospital stay, length of intensive care unit stay or hospitalization costs between the two groups, although timely-recognition group had more chance of renal consult and a little more interventions for AKI. In conclusion, under-recognition of AKI may not be associated with poor short-term outcomes of adult hospitalized patients via these propensity-score-matched analyses.
基金:
Special Foundation for Clinical Science and Technology of Jiangsu Province [BL2014080]; Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions; Jiangsu Province Natural Science Foundation for Youths [BK20151022]; Six Talent Peaks Project in Jiangsu Province [WSN-056]; Blood Purification Quality Control Study of Chinese Hospital Association [CHABP2016-17]