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beta-Asarone Induces Apoptosis and Cell Cycle Arrest of Human Glioma U251 Cells via Suppression of HnRNP A2/B1-Mediated Pathway In Vitro and In Vivo

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收录情况： ◇ SCIE

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机构： [1]College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China [2]Institute of Laboratory Animal Sciences, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu 610212, China

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关键词： beta-asarone glioma apoptosis cell cycle arrest hnRNPA2 B1 alternative splicing

摘要：

HnRNP A2/B1 has been found to be an oncogenic protein strongly related to the growth of human glioma cells. Herein, -asarone, the main component in the volatile oil of Acori tatarinowii Rhizoma, inhibited the cell viability, proliferation, and colony formation ability of U251 cells. Moreover, -asarone induced apoptosis and cell cycle arrest at the G1 phase. Notably, -asarone suppressed the expression of hnRNP A2/B1 and hnRNPA2/B1 overexpression remarkably reversed -asarone-mediated apoptosis and cell cycle arrest. Importantly, -asarone promoted the alternative splicing of Bcl-x by enhancing the ratio of Bcl-xS/Bcl-xL. Meanwhile, hnRNPA2/B1 overexpression mitigated the promoting effect of -asarone on the alternative splicing of Bcl-x. -asarone also regulated the level of the key proteins involved in the death receptor pathway and mitochondrial apoptosis pathway. Additionally, -asarone modulated the cell cycle-related proteins p21, p27, Cdc25A, cyclin D, cyclin E, and CDK2. Finally, -asarone inhibited tumor growth and induced apoptosis in nude mice bearing U251 tumor xenografts. -asarone also suppressed the hnRNP A2/B1 expression, enhanced the expression of cleaved-caspase 3 and p27 and the ratio of Bcl-xS/Bcl-xL, and reduced the expression of CDK2 in U251 xenografts. Together, -asarone-induced apoptosis and cell cycle arrest of U251 cells may be related to the suppression of hnRNPA2/B1-mediated signaling pathway.

基金：

基金编号： 81373903 81202946 cstc2017jcyjAX0299 ZY201702120

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出版当年[2018]版：

大类 | 3 区化学

小类 | 3 区生化与分子生物学 4 区化学综合

最新[2023]版：

大类 | 2 区化学

小类 | 3 区生化与分子生物学 3 区化学：综合

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出版当年[2018]版：

Q2 CHEMISTRY, MULTIDISCIPLINARY Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q2 CHEMISTRY, MULTIDISCIPLINARY

影响因子： 4.2 最新[2023版] 4.6 最新五年平均 3.06 出版当年[2018版] 3.38 出版当年五年平均 3.098 出版前一年[2017版] 3.267 出版后一年[2019版]

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第一作者机构： [1]College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China

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