机构：[1]Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China四川省人民医院四川省肿瘤医院[2]Chengdu Medical College, Chengdu, Sichuan, China
MicroRNAs (miRNAs) are short non-coding RNA molecules that play a significant role in many types of cancers including breast cancer. In the current study, we evaluated the expression levels of microR-10b (miR-10b) in 115 breast cancer patients from Sichuan Cancer Center. Real time reverse transcription-PCR was used to assess miR-10b expression. Clinical data including disease stage, survival status, age, ER/PR/HER2 status, molecular subtypes, tumor size, lymph node status and Ki-67 expression levels were correlated with miR-10b expression levels. Our data showed that the miR-10b expression is correlated with disease stage, living status and tumor sizes. We also found that miR-10b expression levels are higher in the lymph node positive group and the Ki-67 higher scoring group (score > 20). No statistically significant differences were observed based on age or molecular sub-type grouping. In conclusion, miR-10b may be a biomarker for breast cancer and is a potential treatment target.
基金：
Program for provincial universities innovative research team in Sichuan province [13TD0028]
第一作者机构：[1]Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China
通讯作者：
推荐引用方式(GB/T 7714)：
Zhang Jianhui,Yang Jing,Zhang Xin,et al.MicroRNA-10b expression in breast cancer and its clinical association[J].PLOS ONE.2018,13(2):doi:10.1371/journal.pone.0192509.
APA：
Zhang, Jianhui,Yang, Jing,Zhang, Xin,Xu, Jia,Sun, Yiyi&Zhang, Purong.(2018).MicroRNA-10b expression in breast cancer and its clinical association.PLOS ONE,13,(2)
MLA：
Zhang, Jianhui,et al."MicroRNA-10b expression in breast cancer and its clinical association".PLOS ONE 13..2(2018)
