机构：[a]Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China[b]Department of Clinical Laboratory, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610000, China四川省人民医院四川省肿瘤医院[c]Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610000, China四川省人民医院四川省肿瘤医院
Background: Hepatitis B virus (HBV) infection is still a serious public health problem. Understanding risk factors associated with development of HBV is greatly important. Numerous studies focus on relationship between vitamin D receptor (VDR) polymorphisms (Taql, Fokl, Apal, Bsml) and the risk of HBV infection in different ethnic groups. However the results published so far are inconsistent. The aim of this study is to quantify the association between VDR polymorphisms with HBV infection by meta-analysis approach. Methods: A systematic search was performed in Pubmed, Embase, China National Knowledge Infrastructure (CNKI), Database of Chinese Scientific and Technical Periodicals (VIP), and WANFANG. All the relevant studies were published up to October 2016. Results: Finally, 15 published studies included 4218 cases and 2298 controls were included in this meta-analysis. It is interesting to note that Fokl FF tends to be a risk factor for HBV infection [FF vs. ff: P < 0.01, OR (95%CI) = 1.54 (1.19-2.00), I-2 = 0.0%], with no heterogeneity. In addition, genotype Ff and allele F could increase HBV infection risk [Ff vs. ff: P < 0.01, OR (95%CI) = 1.39 (1.13-1.72); F vs. f: P = 0.02, OR (95%CI) = 1.23(1.04-1.45)]. However, no associations were found about VDR TaqI, Apal and Bsml polymorphisms with HBV infection based on each comparison model. Conclusion: This meta-analysis indicates that Fokl genotype FF, Ff and allele F increase the risk of HBV infection. All these results support the notion that VDR Fokl genotype might has potential role in HBV susceptibility.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [30972582]
第一作者机构：[a]Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China[b]Department of Clinical Laboratory, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610000, China
共同第一作者：
通讯作者：
通讯机构：[a]Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China[b]Department of Clinical Laboratory, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610000, China[*1]No. 55, South Renmin Road, Wuhou District, Chengdu 610000, China.[*2]No. 74, Linjiang Road, Yuzhong District, Chongqing 400010, China.
推荐引用方式(GB/T 7714)：
Qiao He,Yecai Huang,Li Zhang,et al.Association between vitamin D receptor polymorphisms and hepatitis B virus infection susceptibility: A meta-analysis study[J].GENE.2018,645:105-112.doi:10.1016/j.gene.2017.12.027.
APA：
Qiao He,Yecai Huang,Li Zhang,Yan Yan,Jingyi Liu...&Weixian Chen.(2018).Association between vitamin D receptor polymorphisms and hepatitis B virus infection susceptibility: A meta-analysis study.GENE,645,
MLA：
Qiao He,et al."Association between vitamin D receptor polymorphisms and hepatitis B virus infection susceptibility: A meta-analysis study".GENE 645.(2018):105-112
