机构：[1]Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China四川大学华西医院[2]Department of Pathology,Case Western Reserve University, Ohio, USA[3]Department of Population and Quantitative Health, School ofMedicine, Case Western Reserve University, Ohio, USA[4]Sichuan Cancer Hospital and Institute, Sichuan CancerCenter, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China四川省人民医院四川省肿瘤医院[5]RadiationOncology Key Laboratory of Sichuan Province, Chengdu, China[6]Department of Neurology and Neurosurgery,McGill University, Montreal, Canada[7]Alan Edwards Centre for Research on Pain, McGill University, Montreal,Canada
Previous studies indicated that both inflammatory responses and hyperglycemia are involved in the similar pathophysiological mechanisms after onset of intracerebral hemorrhage (ICH). However the relationship between hyperglycemia and inflammation remains unknown. We aim to evaluate the associations of hyperglycemia with inflammation and neutrophil to lymphocyte ratio (NLR) in patients with ICH. Patients with acute ICH were retrospectively enrolled. Clinical characteristics and imaging features were obtained. The associations between outcome and laboratory biomarkers were assessed by multivariable logistic regression analysis. Spearman analysis and multiple linear regression analysis were performed to estimate the association of NLR and serum glucose. 175 patients were enrolled. Poor outcome occurred in 86 patients at 30 days. Elevated blood glucose level (BGL) and NLR were strongly associated with outcome in patients with ICH. Moreover, combined NLR-BGL exhibited a better predictive accuracy compared with the peripheral leukocyte counts. Furthermore, there was a robust association between BGL and NLR. We first demonstrated both of NLR and BGL were independently associated with each other. Our results indicate that inflammatory responses and the pathological process of hyperglycemia may influence each other by several complex pathological mechanisms and have a mutual promoting effect to secondary brain injury.
基金：
Sichuan University postdoctoral grant [2017SCU12048]; China postdoctoral science foundationChina Postdoctoral Science Foundation [2018M633373]; Sichuan Health commission grant [18PJ425]; Sichuan province science and technology grant [2015SZ0051]; West China hospital academic excellence grant [2016102]
第一作者机构：[1]Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China[2]Department of Pathology,Case Western Reserve University, Ohio, USA
通讯作者：
通讯机构：[1]Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China[4]Sichuan Cancer Hospital and Institute, Sichuan CancerCenter, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China[5]RadiationOncology Key Laboratory of Sichuan Province, Chengdu, China[6]Department of Neurology and Neurosurgery,McGill University, Montreal, Canada[7]Alan Edwards Centre for Research on Pain, McGill University, Montreal,Canada
推荐引用方式(GB/T 7714)：
Zhang Fan,Ren Yanming,Fu Wei,et al.Association between neutrophil to lymphocyte ratio and blood glucose level at admission in patients with spontaneous intracerebral hemorrhage[J].SCIENTIFIC REPORTS.2019,9:doi:10.1038/s41598-019-52214-5.
APA：
Zhang, Fan,Ren, Yanming,Fu, Wei,Wang, Yuelong,Qian, Juan...&Yang, Mu.(2019).Association between neutrophil to lymphocyte ratio and blood glucose level at admission in patients with spontaneous intracerebral hemorrhage.SCIENTIFIC REPORTS,9,
MLA：
Zhang, Fan,et al."Association between neutrophil to lymphocyte ratio and blood glucose level at admission in patients with spontaneous intracerebral hemorrhage".SCIENTIFIC REPORTS 9.(2019)
