详情页 - 四川省肿瘤医院知识库

当前位置：首页 > 详情页

Treatment abandonment in childhood acute lymphoblastic leukaemia in China: a retrospective cohort study of the Chinese Children's Cancer Group

79| 认领 | 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

机构： [1]Department of Hematology/Oncology, Shanghai Children’s Medical Center,Shanghai Jiao Tong University School of Medicine, Key Lab of Pediatric Hematologyand Oncology of China,Ministry of Health, and National Children’s Medical Center,Shanghai, China [2]Department of Hematology/Oncology, Chongqing Medical University AffiliatedChildren’s Hospital, Chongqing, China [3]Department of Pediatrics, Institute of Hematology and Blood Disease Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin,China [4]Department of Hematology/Oncology, Children’s Hospital of Soochow University,Suzhou, China [5]Department of Pediatrics, West China ,Second University Hospital of SichuanUniversity, Chengdu, China [6]Department of Hematology/Oncology, Guangzhou Women and Children’s HealthCare Center, Guangzhou, China [7]Department of Pediatrics, Southern Medical University Affiliated Nanfang Hospital,Guangzhou, China [8]Department of Hematology/Oncology, Nanjing Children’s Hospital Affiliated toNanjing Medical University, Nanjing, China [9]Department of Hematology/Oncology, Jiangxi Provincial Children’s Hospital,Nanchang, China [10]Department of Pediatrics, Qilu Hospital of Shandong University, Jinan, China [11]Department of Hematology/Oncology, Kunming Children’s Hospital, Kunming,China [12]Department of Hematology/Oncology, Children’s Hospital of Fudan University,Shanghai, China [13]Department of Pediatrics, Huazhong University of Science and Technology TongjiMedical College Union Hospital, Wuhan, China [14]Department of Pediatrics, Huazhong University of Science and Technology TongjiMedical College Tongji Hospital, Wuhan, China [15]Department of Pediatrics, Anhui Medical University Second Affiliated Hospital,Hefei, China [16]Department of Hematology/Oncology, Children’s Hospital Affiliated to ShanghaiJiao Tong University, Shanghai, China [17]Department of Pediatrics, Qingdao University Affiliated Hospital, Qingdao, China [18]Deparment of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong [19]Department of Hematology/Oncology, Northwest Women’s and Children’s Hospital,Xi’an, China [20]Department of Pediatrics, Xiangya Hospital Central South University, Changsha,Hunan, China [21]Department of Biostatistics, St Jude Children’s Research Hospital, Memphis,Tennessee, USA22Department of Oncology, St Jude Children’s Research Hospital, Memphis, USA

出处：

DOI：

ISSN：

摘要：

Objectives Before 2003, most children with acute lymphoblastic leukaemia (ALL) abandoned treatment, with only approximately 30% treated in China. With the development of national insurance for underprivileged patients, we assessed the current frequency and causes of treatment abandonment among patients with ALL who were enrolled in the Chinese Children's Cancer Group ALL protocol between 2015 and 2016. Methods Demographic, clinical and laboratory data on patients who abandoned treatment, as well as economic and sociocultural data of their families were collected and analysed. General health-related statistics were retrieved from publicly accessible databanks maintained by the Chinese government. Results At a median follow-up of 119 weeks, 83 (3.1%, 95% CI 2.5% to 3.8%) of the 2641 patients abandoned treatment. Factors independently associated with abandonment included standard/high-risk ALL (OR 2.62, 95% CI 1.43 to 4.77), presence of minimal residual disease at the end of remission induction (OR 3.57, 95% CI 1.90 to 6.74) and low-income economic region (OR 3.7, 95% CI 1.89 to 7.05). According to the family members, economic constraints (50.6%, p=0.0001) were the main reason for treatment abandonment, followed by the belief of incurability, severe side effects and concern over late complications. Conclusions The rate of ALL treatment abandonment has been greatly reduced in China. Standard/high-risk ALL, residence in a low-income region and economic difficulties were associated with treatment abandonment.

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2019]版：

大类 | 2 区医学

小类 | 2 区儿科

最新[2023]版：

大类 | 3 区医学

小类 | 2 区儿科

JCR分区：

出版当年[2019]版：

Q1 PEDIATRICS

最新[2023]版：

Q1 PEDIATRICS

影响因子： 4.3 最新[2023版] 3.9 最新五年平均 3.041 出版当年[2019版] 3.293 出版当年五年平均 3.158 出版前一年[2018版] 3.801 出版后一年[2020版]

第一作者：

第一作者机构： [1]Department of Hematology/Oncology, Shanghai Children’s Medical Center,Shanghai Jiao Tong University School of Medicine, Key Lab of Pediatric Hematologyand Oncology of China,Ministry of Health, and National Children’s Medical Center,Shanghai, China

通讯作者：

通讯机构： [1]Department of Hematology/Oncology, Shanghai Children’s Medical Center,Shanghai Jiao Tong University School of Medicine, Key Lab of Pediatric Hematologyand Oncology of China,Ministry of Health, and National Children’s Medical Center,Shanghai, China [*1]Department of Oncology, St Jude Children’s Research Hospital, Memphis, Tennessee, USA [*2]Department of Hematology/ Oncology, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Key Lab of Pediatric Hematology and Oncology of China Ministry of Health, Shanghai 200127, China

推荐引用方式(GB/T 7714)：

APA：

MLA：