Clinicopathologic and Prognostic Significance of Body Mass Index (BMI) among Breast Cancer Patients in Western China: A Retrospective Multicenter Cohort Based on Western China Clinical Cooperation Group (WCCCG)
机构：[1]Department of the Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China重庆医科大学附属第一医院[2]Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, China[3]Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China[4]Department of Breast and Neck Surgery, Affiliated Tumor Hospital of XinjiangMedical University, Urumqi, Xinjiang, China[5]Department of Breast Surgery, Sichuan Province Tumor Hospital, Chengdu, Sichuan, China外科中心乳腺外科中心四川省肿瘤医院乳腺科[6]Department of Breast Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, Sichuan, China四川省人民医院[7]Breast Disease Center, Southwest Hospital, Third Military Medical University, No. 29 Gaotanyan Street, Chongqing 400038, China[8]West China Hospital/West China School of Nursing, Sichuan University, China四川大学华西医院[9]Institute of Hospital Management,West China Hospital, Sichuan University, China四川大学华西医院[10]Division of Biostatistics and Data Science, Department of Population Health Sciences, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA[11]Chongqing Key Laboratory of Molecular Oncology and Epigenetics,The First Affiliated Hospital of Chongqing Medical University, Chongqing, China重庆医科大学附属第一医院
Introduction. Clinicopathologic and prognostic significance of body mass index (BMI) in breast cancer (BC) patients remained conflicting. We aimed to investigate and modify the impact of BMI on clinicopathological significance and survival in western Chinese BC patients. Materials and Methods. 8,394 female BC patients from Western China Clinical Cooperation Group (WCCCG) between 2005 and 2015 were identified. Multivariable logistic regression and Cox proportion hazard regressions were used to examine the difference of clinicopathologic and survival characteristics between BMI categories. Results. For the premenopausal, overweight and obese (OW) patients tended to have large tumor size (>5cm) (odds ratio [OR], 1.30, P<0.01) and triple-negative BC (OR, 1.31; P=0.01) compared with normal weight (NW) patients. Premenopausal underweight (UW) patients had a significantly higher risk of HER2 positive (OR, 1.71; P=0.02) and distant metastasis (OR, 2.59; P=0.01). For postmenopausal patients, OW patients showed higher risks of large tumor size (>5cm) (OR, 1.46; P=0.01), nuclear grade III (OR, 1.24; P=0.04), and lymphovascular invasion (OR, 1.46; P=0.01) compared with NW patients. An U shaped relationship between BMI and DFS was found (UW versus NW, adjusted hazard ratio (HR), 2.80, P<0.001; OW versus NW, adjusted HR, 1.40, P=0.02), whereas no significant difference of disease-free survival (DFS) between OW and NW premenopausal patients (adjusted HR=1.34, P=0.18) was revealed. Conclusion. We concluded that UW and OW were associated with aggressively clinicopathological characteristics, regardless of menopausal status. An U shaped association of BMI and DFS was revealed, and no significant difference of DFS between OW and NW in postmenopausal subgroup was revealed.
基金：
Peking Union Medical College [2014BAI08B03]; Zhejiang Province Key Project of Science and Technology [2014BAI08B00]; Chinese Academy of Medical Sciences; National Key Clinical Specialty Construction Program of China
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|4 区生物学
小类|4 区生物工程与应用微生物4 区医学：研究与实验
最新[2023]版：
无
JCR分区：
出版当年[2019]版：
Q3BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ3MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q3BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ3MEDICINE, RESEARCH & EXPERIMENTAL
第一作者机构：[1]Department of the Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of the Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China[11]Chongqing Key Laboratory of Molecular Oncology and Epigenetics,The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
推荐引用方式(GB/T 7714)：
Wang Kang,Wu Yu-Tuan,Zhang Xiang,et al.Clinicopathologic and Prognostic Significance of Body Mass Index (BMI) among Breast Cancer Patients in Western China: A Retrospective Multicenter Cohort Based on Western China Clinical Cooperation Group (WCCCG)[J].BIOMED RESEARCH INTERNATIONAL.2019,2019:doi:10.1155/2019/3692093.
APA：
Wang, Kang,Wu, Yu-Tuan,Zhang, Xiang,Chen, Li,Zhu, Wen-Ming...&Li, Hong-Yuan.(2019).Clinicopathologic and Prognostic Significance of Body Mass Index (BMI) among Breast Cancer Patients in Western China: A Retrospective Multicenter Cohort Based on Western China Clinical Cooperation Group (WCCCG).BIOMED RESEARCH INTERNATIONAL,2019,
MLA：
Wang, Kang,et al."Clinicopathologic and Prognostic Significance of Body Mass Index (BMI) among Breast Cancer Patients in Western China: A Retrospective Multicenter Cohort Based on Western China Clinical Cooperation Group (WCCCG)".BIOMED RESEARCH INTERNATIONAL 2019.(2019)
