Clinical outcome and prognostic analysis of young adults nasopharyngeal carcinoma patients of a nonendemic area in intensity-modulated radiotherapy era
机构：[1]Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science & Technology of China, Chengdu, PR China四川省肿瘤医院[2]Department of Oncology, People’s Hospital of Wenjiang District, Chengdu, PR China[3]Department of Clinical Laboratory, Sichuan Cancer Center, School of Medicine, University of Electronic Science & Technology of China, Chengdu, PR China四川省肿瘤医院
Aim: To investigate the clinical outcome and prognostic factors of young adults nasopharyngeal carcinoma (NPC) patients in the era of intensity-modulated radiotherapy. Methods: We retrospectively analyzed the clinical outcome and the prognostic factors of young adults NPC patients who were admitted to our hospital from January 2010 to December 2013. COX regression model was used to identify factors associated with survival. The acute and late toxicities were also evaluated. Results: A total of 165 patients were included; the median follow-up time for all the patients was 65 months (4-96 months). The 5-year overall survival (OS), distant metastasis-free survival, progression-free survival and local-regional recurrence-free survival were 85.9, 82.4, 76.4 and 92.4%, respectively. N stage was an independent prognostic factor for OS (p = 0.009) and distant metastasis-free survival (p = 0.008). Cumulative cisplatin > 200 mg/m(2) was an independent prognostic factor for OS (p = 0.032). Conclusion: Young adults with NPC can achieve a reasonable local-regional control and OS in the era of intensity-modulated radiotherapy with tolerable toxicities.
基金：
Chinese Society of Clinical Oncology (CSCO) Clinical Oncology Research Funding [Y-MT2016-017]; Science and Technology Program Project Funds of Sichuan Province [2015SZ0053]
第一作者机构：[1]Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science & Technology of China, Chengdu, PR China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science & Technology of China, Chengdu, PR China
推荐引用方式(GB/T 7714)：
Huang Yecai,Zhang Jingqiu,He Qiao,et al.Clinical outcome and prognostic analysis of young adults nasopharyngeal carcinoma patients of a nonendemic area in intensity-modulated radiotherapy era[J].FUTURE ONCOLOGY.2019,15(4):381-389.doi:10.2217/fon-2018-0547.
APA：
Huang, Yecai,Zhang, Jingqiu,He, Qiao,Ian, Mei,Feng, Mei...&Lang, Jinyi.(2019).Clinical outcome and prognostic analysis of young adults nasopharyngeal carcinoma patients of a nonendemic area in intensity-modulated radiotherapy era.FUTURE ONCOLOGY,15,(4)
MLA：
Huang, Yecai,et al."Clinical outcome and prognostic analysis of young adults nasopharyngeal carcinoma patients of a nonendemic area in intensity-modulated radiotherapy era".FUTURE ONCOLOGY 15..4(2019):381-389
