Preoperative platelet-lymphocyte ratio is a superior prognostic biomarker to other systemic inflammatory response markers in non-small cell lung cancer
机构：[1]Department of Oncology, Chengdu First Peoples’ Hospital, Chengdu 610041, Sichuan, China[2]Department of Radiotherapy, Sichuan Cancer Hospital & Institute,Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.四川省人民医院四川省肿瘤医院腹盆部放疗放射治疗中心[3]Department of Thoracic Surgery, Sichuan Cancer Hospital & Institute,Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.外科中心胸外科中心四川省人民医院四川省肿瘤医院胸外科
Systemic inflammatory response markers are associated with poor survival in many types of malignances. This study aimed to evaluate the prognostic value of preoperative neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), lymphocyte-monocyte ratio (LMR), and C-reactive protein (CRP) in patients with non-small cell lung cancer (NSCLC). We retrospectively evaluated 254 NSCLC patients who underwent radical surgery between January 2012 and April 2014 in the Sichuan Provincial Cancer Hospital. The cut-off values of NLR, PLR, LMR, and CRP were determined according to the receiver operating characteristic curve, and the correlation of NLR, PLR, LMR, and CRP with prognosis was analyzed based on the cut-off value. The cut-off value for NLR, PLR, LMR, and CRP were 3.18, 122, 4.04, and 8.8, respectively. Univariate analysis showed that age (P = .022), tumor-node-metastasis (TNM) stage (P < .001), T stage (P = .001), and N stage (P < .001) were significantly correlated with disease-free survival (DFS), while age (P = .011), TNM stage (P < .001), T stage (P = .008), N stage (P < .001), and PLR (P = .001) were significantly correlated with overall survival (OS). In multivariate analysis, age (hazard ratio [HR]: 1.564, 95% confidence interval [CI]: 1.087-2.252, P = .016) and TNM stage (HR: 1.704, 95% CI: 1.061-2.735, P = .027) remained independent risk factors affecting DFS, while age (HR: 1.721, 95% CI: 1.153-2.567, P = .008), TNM stage (HR: 2.198, 95% CI: 1.263-3.824, P = .005), and PLR (HR: 1.850, 95% CI: 1.246-2.746, P = .002) were independent risk factors affecting OS. The preoperative PLR is superior to NLR, LMR, and CRP as a biomarker for evaluating the prognosis of patients undergoing curative surgery for NSCLC.
基金：
Project of Sichuan Provincial Science and Technology [2017SZ0004]
第一作者机构：[1]Department of Oncology, Chengdu First Peoples’ Hospital, Chengdu 610041, Sichuan, China[*1]Department of Oncology, Chengdu First Peoples’ Hospital, Chengdu 610041, Sichuan, China
通讯作者：
通讯机构：[1]Department of Oncology, Chengdu First Peoples’ Hospital, Chengdu 610041, Sichuan, China[2]Department of Radiotherapy, Sichuan Cancer Hospital & Institute,Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.[*1]Department of Oncology, Chengdu First Peoples’ Hospital, Chengdu 610041, Sichuan, China[*2]Department of Radiotherapy, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China
推荐引用方式(GB/T 7714)：
Huang Qing,Diao Peng,Li Chang-Lin,et al.Preoperative platelet-lymphocyte ratio is a superior prognostic biomarker to other systemic inflammatory response markers in non-small cell lung cancer[J].MEDICINE.2020,99(4):doi:10.1097/MD.0000000000018607.
APA：
Huang, Qing,Diao, Peng,Li, Chang-Lin,Peng, Qian,Xie, Tianpeng...&Lang, Jin-Yi.(2020).Preoperative platelet-lymphocyte ratio is a superior prognostic biomarker to other systemic inflammatory response markers in non-small cell lung cancer.MEDICINE,99,(4)
MLA：
Huang, Qing,et al."Preoperative platelet-lymphocyte ratio is a superior prognostic biomarker to other systemic inflammatory response markers in non-small cell lung cancer".MEDICINE 99..4(2020)
