机构：[1]State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Shanghai Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Er Road, Shanghai 200025, China[2]School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China[3]Department of Otolaryngology, Shanghai Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China[4]Department of Pathology, Shanghai Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China[5]Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China华中科技大学同济医学院附属协和医院[6]Department of Hematology, Xinqiao Hospital, Third Military Medical University, Chongqing, China[7]Department of Hematology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China[8]Department of Hematology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China浙江大学医学院附属第一医院[9]Department of Hematology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China[10]Department of Hematology, The Third Affiliated Hospital of Suzhou University, The First People’s Hospital of Changzhou, Changzhou, People’s Republic of China[11]Fujian Institute of Hematology, Fujian Medical University Union Hospital, Fuzhou, China[12]Department of Hematology, Qilu Hospital of Shandong University, Jinan, China[13]Department of Medical Oncology, Shanghai Cancer Center, Fudan University, Shanghai, China[14]Department of Hematology, Shandong Province Hospital of Shandong University, Jinan, China[15]Department of Medical Oncology, Jiangsu Cancer Hospital, Nanjing, China[16]Department of Hematology, Henan Province People’s Hospital, Zhengzhou, China[17]Department of Hematology, Sichuan Provincial People’s Hospital, Chengdu, China四川省人民医院[18]Department of Hematology, Tangdu Hospital, The Fourth Military Medical University, Xi’an, China[19]Department of Hematology, Lanzhou University Second Hospital, Lanzhou, Gansu, China[20]Department of Oncology and Hematology, Hospital (T.C.M) Affiliated to Southwest Medical University, Luzhou, China[21]Department of Hematology, Wuxi People’s Hospital Affiliated to Nanjing Medical University, Wuxi, China[22]Department of Hematology, The First Affiliated Hospital of Nanchang University, Nanchang, China[23]Department of Hematology, Nanjing Drum Tower Hospital, Nanjing, China[24]Department of Hematology, Shanghai General Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China[25]Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China[26]Department of Hematology, The Second Affiliated Hospital of Nanchang University, Nanchang, China[27]Poˆ le de Recherches Sino-Franc¸ ais en Science du Vivant et Ge´ nomique, Laboratory of Molecular Pathology, Shanghai, China
Natural killer/T cell lymphoma (NKTCL) is an aggressive and heterogeneous entity of non-Hodgkin lymphoma, strongly associated with Epstein-Barr virus (EBV) infection. To identify molecular subtypes of NKTCL based on genomic structural alterations and EBV sequences, we performed multi-omics study on 128 biopsy samples of newly diagnosed NKTCL and defined three prominent subtypes, which differ significantly in cell of origin, EBV gene expression, transcriptional signatures, and responses to asparaginase-based regimens and targeted therapy. Our findings thus identify molecular networks of EBV-associated pathogenesis and suggest potential clinical strategies on NKTCL.
第一作者机构：[1]State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Shanghai Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Er Road, Shanghai 200025, China
共同第一作者：
通讯作者：
通讯机构：[1]State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Shanghai Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Er Road, Shanghai 200025, China[27]Poˆ le de Recherches Sino-Franc¸ ais en Science du Vivant et Ge´ nomique, Laboratory of Molecular Pathology, Shanghai, China
推荐引用方式(GB/T 7714)：
Xiong Jie,Cui Bo-Wen,Wang Nan,et al.Genomic and Transcriptomic Characterization of Natural Killer T Cell Lymphoma[J].CANCER CELL.2020,37(3):403-+.doi:10.1016/j.ccell.2020.02.005.
APA：
Xiong, Jie,Cui, Bo-Wen,Wang, Nan,Dai, Yu-Ting,Zhang, Hao...&Zhao, Wei-Li.(2020).Genomic and Transcriptomic Characterization of Natural Killer T Cell Lymphoma.CANCER CELL,37,(3)
MLA：
Xiong, Jie,et al."Genomic and Transcriptomic Characterization of Natural Killer T Cell Lymphoma".CANCER CELL 37..3(2020):403-+
医学