机构：[1]Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, 300052 Tianjin, China[2]Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, 450052 Zhengzhou, China[3]Department of Radiology, Zhengzhou University People’s Hospital and Henan Provincial People’s Hospital, 450003 Zhengzhou, China[4]Henan Key Laboratory for Medical Imaging of Neurological Diseases, 450003 Zhengzhou, China[5]Department of Medical Imaging, The Second Hospital of Hebei Medical University, 050000 Shijiazhuang, China[6]Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China华中科技大学同济医学院附属同济医院[7]Department of Radiology, Drum Tower Hospital, Medical School of Nanjing University, 210008 Nanjing, China[8]Department of Radiology, Xiangya Hospital, Central South University, 410008 Changsha, China[9]National Clinical Research Center for Geriatric Disorder, 410008 Changsha, China[10]Department of Medical Imaging, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, 510405 Guangzhou, China深圳市中医院深圳医学信息中心[11]Department of Radiology, The First Hospital of Shanxi Medical University, 030001 Taiyuan, China[12]Department of Radiology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, 310009 Hangzhou, China[13]Department of Radiology, The First Affiliated Hospital of Anhui Medical University, 230022 Hefei, China[14]Department of Radiology, Yantai Yuhuangding Hospital, 264000 Yantai, China[15]Department of Radiology, Tianjin Huanhu Hospital, 300350 Tianjin, China[16]Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, 300350 Tianjin, China[17]Department of Radiology, Huashan Hosptial, Fudan University, 200040 Shanghai, China[18]Functional and Molecular Imaging Key Lab of Shaanxi Province & Department of Radiology, Tangdu Hospital, The Military Medical University of PLA Airforce (Fourth Military Medical University), 710038 Xi’an, China[19]Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Key Laboratory of Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, 300070 Tianjin, China[20]School of Medical Imaging, Tianjin Medical University, 300203 Tianjin, China[21]Department of Radiology, Hainan General Hospital, 570311 Haikou, China[22]Department of Radiology, Beijing Tongren Hospital, Capital Medical University, 100730 Beijing, China首都医科大学附属同仁医院[23]Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, 325000 Wenzhou, China[24]Department of Magnetic Resonance, Lanzhou University Second Hospital, 730050 Lanzhou, China[25]Department of Psychology, University of Chinese Academy of Sciences (CAS), 100049 Beijing, China[26]CAS Key Laboratory of Behavioral Science, Institute of Psychology, 100101 Beijing, China[27]Department of Radiology, Qilu Hospital of Shandong University, 250012 Jinan, China[28]Department of Radiology, Tianjin First Center Hospital, 300192 Tianjin, China[29]Department of Radiology, The First Affiliated Hospital of Dalian Medical University, 116011 Dalian, China大连医科大学附属第一医院[30]Department of Radiology, Pingjin Hospital, Logistics University of Chinese People’s Armed Police Forces, 300162 Tianjin, China[31]Department of Radiology, The Center for Medical Imaging, West China Hospital of Sichuan University, 610041 Chengdu, China四川大学华西医院[32]Department of Radiology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, 325000 Wenzhou, China[33]CAS Key Laboratory of Brain Function and Disease, University of Science and Technology of China, 230026 Hefei, China[34]School of Life Sciences, University of Science & Technology of China, 230026 Hefei, China[35]Department of Radiology, The Affiliated Hospital of Xuzhou Medical University, 221006 Xuzhou, China[36]School of Medical Imaging, Xuzhou Medical University, 221004 Xuzhou, China[37]Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, 210002 Nanjing, China[38]Department of Radiology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, 300060 Tianjin, China[39]CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China
The Chinese Imaging Genetics (CHIMGEN) study establishes the largest Chinese neuroimaging genetics cohort and aims to identify genetic and environmental factors and their interactions that are associated with neuroimaging and behavioral phenotypes. This study prospectively collected genomic, neuroimaging, environmental, and behavioral data from more than 7000 healthy Chinese Han participants aged 18-30 years. As a pioneer of large-sample neuroimaging genetics cohorts of non-Caucasian populations, this cohort can provide new insights into ethnic differences in genetic-neuroimaging associations by being compared with Caucasian cohorts. In addition to micro-environmental measurements, this study also collects hundreds of quantitative macro-environmental measurements from remote sensing and national survey databases based on the locations of each participant from birth to present, which will facilitate discoveries of new environmental factors associated with neuroimaging phenotypes. With lifespan environmental measurements, this study can also provide insights on the macro-environmental exposures that affect the human brain as well as their timing and mechanisms of action.
基金：
This work was supported in part by the National Key
Research and Development Program of China (Grant No.
2018YFC1314301) and the National Natural Science Foundation of
China (Grant No. 81425013) contributing to the initiation of the
project.
第一作者机构：[1]Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, 300052 Tianjin, China
通讯作者：
通讯机构：[1]Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, 300052 Tianjin, China[39]CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China
推荐引用方式(GB/T 7714)：
Qiang Xu,Lining Guo,Jingliang Cheng,et al.CHIMGEN: a Chinese imaging genetics cohort to enhance cross-ethnic and cross-geographic brain research[J].MOLECULAR PSYCHIATRY.2020,25(3):517-529.doi:10.1038/s41380-019-0627-6.
APA：
Qiang Xu,Lining Guo,Jingliang Cheng,Meiyun Wang,Zuojun Geng...&the CHIMGEN Consortium.(2020).CHIMGEN: a Chinese imaging genetics cohort to enhance cross-ethnic and cross-geographic brain research.MOLECULAR PSYCHIATRY,25,(3)
MLA：
Qiang Xu,et al."CHIMGEN: a Chinese imaging genetics cohort to enhance cross-ethnic and cross-geographic brain research".MOLECULAR PSYCHIATRY 25..3(2020):517-529
医学