机构：[1]Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol So China, Dept Med Oncol, Guangzhou 510060, Guangdong, Peoples R China临床科室其他部门内科华南肿瘤学国家重点实验室中山大学肿瘤防治中心[2]Sun Yat Sen Univ, Affiliated Hosp 2, State Key Lab Oncol So China, Guangzhou 510060, Guangdong, Peoples R China其他部门华南肿瘤学国家重点实验室中山大学肿瘤防治中心[3]Sun Yat Sen Univ, Affiliated Hosp 2, Dept Urol, Guangzhou 510060, Guangdong, Peoples R China[4]Sun Yat Sen Univ, Affiliated Hosp 2, Lin Bai Xin Med Res Ctr, Guangzhou 510060, Guangdong, Peoples R China[5]Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol So China, Dept Med Oncol, 651 Dong Feng RD E, Guangzhou 510060, Guangdong, Peoples R China临床科室其他部门内科华南肿瘤学国家重点实验室中山大学肿瘤防治中心
The expression of phosphorylated AKT (pAKT) in peripheral T-cell lymphomas (PTCL) and its clinical significance were studied. We detected pAKT expression by using the immunohistochemical method in 106 cases of PTCL. Positive pAKT expression was detected in 49.1% of patients, was negatively correlated with overall response rate, and predicted decreased progression-free survival and/or overall survival. Our results suggest that pAKT expression is an independent prognostic factor for PTCL. Background: The AKT signaling pathway controls the survival and growth of human cancer cells. The purpose of this study was to investigate the expression dynamics of phosphorylated AKT (pAKT) in peripheral T-cell lymphoma (PTCL) and its clinical significance. Materials and Methods: Immunohistochemistry was performed to examine the pAKT expression in 106 PTCL cases. pAKT expression and its association with clinicopathologic characteristics of a patient with PTCL were analyzed. Results: A total of 106 samples were tested, and 52 (49.1%) were positive for pAKT. There was significant positive correlation between pAKT expression and higher levels of lactic dehydrogenase (P<.05), whereas positive pAKT expression was negatively correlated with patients' overall response rate (P<.05). Further multivariate analysis revealed that positive pAKT expression predicted decreased progression-free survival and/or overall survival (P<.05). Conclusion: Analysis of our results suggest that pAKT expression, as examined by immunohistochemistry, is an independent prognostic factor for PTCL. The clinical value of pAKT expression analysis in PTCL is worthy of further clinical investigations.
基金：
National Nature Scientific Research Fund of China [81001052]; Science and Technology Planning Project of Guangdong Province, China [2011B031800222]; Sun Yat-Sen University Cancer Center
语种：
外文
被引次数：
WOS：
中科院(CAS)分区：
出版当年[2012]版：
大类|4 区医学
小类|4 区血液学4 区肿瘤学
最新[2023]版：
大类|4 区医学
小类|4 区血液学4 区肿瘤学
第一作者：
第一作者机构：[2]Sun Yat Sen Univ, Affiliated Hosp 2, State Key Lab Oncol So China, Guangzhou 510060, Guangdong, Peoples R China
通讯作者：
通讯机构：[1]Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol So China, Dept Med Oncol, Guangzhou 510060, Guangdong, Peoples R China[2]Sun Yat Sen Univ, Affiliated Hosp 2, State Key Lab Oncol So China, Guangzhou 510060, Guangdong, Peoples R China[5]Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol So China, Dept Med Oncol, 651 Dong Feng RD E, Guangzhou 510060, Guangdong, Peoples R China
推荐引用方式(GB/T 7714)：
Cai Qingqing,Deng Haixia,Xie Dan,et al.Phosphorylated AKT Protein Is Overexpressed in Human Peripheral T-cell Lymphomas and Predicts Decreased Patient Survival[J].CLINICAL LYMPHOMA MYELOMA & LEUKEMIA.2012,12(2):106-112.doi:10.1016/j.clml.2011.12.002.
APA：
Cai, Qingqing,Deng, Haixia,Xie, Dan,Lin, Tianxin&Lin, Tongyu.(2012).Phosphorylated AKT Protein Is Overexpressed in Human Peripheral T-cell Lymphomas and Predicts Decreased Patient Survival.CLINICAL LYMPHOMA MYELOMA & LEUKEMIA,12,(2)
MLA：
Cai, Qingqing,et al."Phosphorylated AKT Protein Is Overexpressed in Human Peripheral T-cell Lymphomas and Predicts Decreased Patient Survival".CLINICAL LYMPHOMA MYELOMA & LEUKEMIA 12..2(2012):106-112
