Screening for circulating tumor cells (CTCs) has been identified as one approach to ultrasensitive liquid biopsy in real-time monitoring of cancer patients. The detection of CTCs in peripheral blood from cancer patients is promising as a diagnostic tool; however, the application of CTCs in therapeutic treatment still faces serious challenges with respect to specificity and sensitivity. Here, we review the significant roles of CTCs in metastasis and the strengths and weaknesses of the currently available methods for CTC detection and characterization. Moreover, we discuss the clinical application of CTCs as markers for patient prognosis, and we specifically focus on the application of CTCs as indicators in cancer pharmacotherapy. Characterization of the detected CTCs will provide new biologic perspectives and clinical applications for the treatment of cancer patients with metastasis.
基金：
National Nature Scientific Foundation [81473233, 81600878]; International Collaboration Science Research Foundation of Guangdong Province [2013B051000046]; Medical Science and Technology Research Fund of Guangdong Province [B2013145]; Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2016A030310217]; Medical Scientific Research Foundation of Guangdong Province [A2016096]
语种：
外文
被引次数：
WOS：
中科院(CAS)分区：
出版当年[2017]版：
大类|2 区医学
小类|2 区药学
最新[2023]版：
大类|3 区医学
小类|3 区药学
第一作者：
第一作者机构：[1]Sun Yat Sen Univ, Guangdong Esophageal Canc Inst, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Guangzhou, Guangdong, Peoples R China;[2]Sun Yat Sen Univ, Guangdong Prov Key Lab Stomatol, Guanghua Sch Stomatol, Dept Oral Med, Guangzhou, Guangdong, Peoples R China;
通讯作者：
通讯机构：[1]Sun Yat Sen Univ, Guangdong Esophageal Canc Inst, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Guangzhou, Guangdong, Peoples R China;[3]Sun Yat Sen Univ, Ctr Canc, Canc Inst, Guangzhou 510060, Guangdong, Peoples R China
推荐引用方式(GB/T 7714)：
Wu Tong,Cheng Bin,Fu Liwu.Clinical Applications of Circulating Tumor Cells in Pharmacotherapy: Challenges and Perspectives[J].MOLECULAR PHARMACOLOGY.2017,92(3):232-239.doi:10.1124/mol.116.108142.
APA：
Wu, Tong,Cheng, Bin&Fu, Liwu.(2017).Clinical Applications of Circulating Tumor Cells in Pharmacotherapy: Challenges and Perspectives.MOLECULAR PHARMACOLOGY,92,(3)
MLA：
Wu, Tong,et al."Clinical Applications of Circulating Tumor Cells in Pharmacotherapy: Challenges and Perspectives".MOLECULAR PHARMACOLOGY 92..3(2017):232-239
