机构:[1]Chinese Acad Sci, Shenzhen Inst Adv Technol, Paul C Lauterbur Res Ctr Biomed Imaging, Shenzhen, Guangdong, Peoples R China;[2]Sun Yat Sen Univ, Dept Neurosurg, Canc Ctr, Guangzhou, Guangdong, Peoples R China中山大学肿瘤防治中心
出处:
ISSN:
摘要:
Magnetic resonance amide proton transfer (APT) imaging has proved its potential for detecting tumors and evaluating treatment response by depicting chemical exchange saturation transfer effect between the endogenous protein/peptide amide proton and bulk water. However, conventional asymmetry analysis for APT effect measurement is susceptible to concomitant contributions, particular semisolid magnetic transfer (MT) and nuclear overhauser effect. In this study, dominant saturation transfer (ST) effects, including direct water saturation and MT, were estimated from a sum of two Lorentzian functions. APT effect was then quantified by subtracting the Z-spectrum with the two ST effects. Feasibility of the method in the assessment of glioma therapeutic response was investigated in a rodent model at 3 Tesla.
基金:
NSFCNational Natural Science Foundation of China [81571668]; National Basic Research Program of ChinaNational Basic Research Program of China [2015CB755500]; SSTP [GJHZ20160229200622417]
语种:
外文
第一作者:
第一作者机构:[1]Chinese Acad Sci, Shenzhen Inst Adv Technol, Paul C Lauterbur Res Ctr Biomed Imaging, Shenzhen, Guangdong, Peoples R China;
通讯作者:
通讯机构:[1]Chinese Acad Sci, Shenzhen Inst Adv Technol, Paul C Lauterbur Res Ctr Biomed Imaging, Shenzhen, Guangdong, Peoples R China;
推荐引用方式(GB/T 7714):
Zhao Jing,Chen Yinsheng,Zhao Yiying,et al.Assessment of Chemoradiotherapy Response in Glioma with Magnetic Resonance Amide Proton Transfer Imaging in a Rodent Model[J].2017 39TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC).2017,541-543.
APA:
Zhao, Jing,Chen, Yinsheng,Zhao, Yiying,Yang, Shasha,Chen, Zhongping&Wu, Yin.(2017).Assessment of Chemoradiotherapy Response in Glioma with Magnetic Resonance Amide Proton Transfer Imaging in a Rodent Model.2017 39TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC),,
MLA:
Zhao, Jing,et al."Assessment of Chemoradiotherapy Response in Glioma with Magnetic Resonance Amide Proton Transfer Imaging in a Rodent Model".2017 39TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC) .(2017):541-543