Both mesenchymal stromal cells (MSCs) and myeloid-derived suppressor cells (MDSCs) have immunosuppressive properties, and their presence may confer a worse prognosis upon cancer patients. However, whether MSCs can enhance the immunosuppressive effects of MDSCs in MM remains unknown. We evaluated the influence of MSCs on MDSCs growth, apoptosis, and functions. Our results show that MSCs promote proliferation and inhibit apoptosis in MDSCs. Additionally, MSCs enhance the ability of MDSCs by inhibiting T-cell proliferation and IFN- production. Furthermore, both the mRNA and protein levels of Arg1 and NOS2 were upregulated in MDSCs. These results suggest that MSCs may exert immunomodulatory effects on MDSCs by upregulating Arg1 and NOS2.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81272562]
语种：
外文
被引次数：
WOS：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区医学
小类|3 区血液学3 区肿瘤学
最新[2025]版：
大类|4 区医学
小类|4 区血液学4 区肿瘤学
第一作者：
第一作者机构：[1]Guilin Med Univ, Affiliated Hosp 2, Thorac Surg, Guilin, Guangxi, Peoples R China
通讯作者：
通讯机构：[2]Tianjin Med Univ, Canc Hosp Tianjin, Dept Hematol, Key Lab Canc Prevent & Therapy, Tianjin, Peoples R China
推荐引用方式(GB/T 7714)：
Xu Yinhui,Zhang Xiaoying,Liu Hongbo,et al.Mesenchymal stromal cells enhance the suppressive effects ofmyeloid-derived suppressor cells of multiple myeloma[J].LEUKEMIA & LYMPHOMA.2017,58(11):2668-2676.doi:10.1080/10428194.2017.1298753.
