SOX4 (sex-determining region Y-related high-mobility group box 4) is associated with tumor progression and poor clinical outcome in several cancers. This study aims to evaluate whether SOX4 affects the biological behaviors of prostate cancer and further elucidate whether this effect works through the epithelial-mesenchymal transition pathway. We investigated the expression of SOX4 in a series of prostate cancer tissues and adjacent noncancerous tissues, as well as in a panel of prostate cancer cell lines. Cell proliferation, migration, and invasion were evaluated in SOX4 knockdown prostate cancer cell lines by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and Transwell assay. Our results showed that the expression of SOX4 was remarkably upregulated both in prostate cancer tissues and in cell lines. Knockdown of SOX4 repressed the ability of cell proliferation and migration of DU145 cells. Moreover, inhibition of SOX4 could reverse the epithelial-mesenchymal transition processes through upregulation of E-cadherin and downregulation of vimentin. This study provided evidence that SOX4 could serve as a potential therapeutic target in prostate cancer.
语种：
外文
被引次数：
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PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|2 区医学
小类|3 区肿瘤学
最新[2023]版：
无
第一作者：
第一作者机构：[1]Guangzhou Med Univ, Affiliated Hosp 5, Dept Urol, Guangzhou 510000, Guangdong, Peoples R China;
通讯作者：
通讯机构：[1]Guangzhou Med Univ, Affiliated Hosp 5, Dept Urol, Guangzhou 510000, Guangdong, Peoples R China;
推荐引用方式(GB/T 7714)：
Liu Yifan,Zeng Shan,Jiang Xianhan,et al.SOX4 induces tumor invasion by targeting EMT-related pathway in prostate cancer[J].TUMOR BIOLOGY.2017,39(5):-.doi:10.1177/1010428317694539.
APA：
Liu, Yifan,Zeng, Shan,Jiang, Xianhan,Lai, Dehui&Su, Zhengming.(2017).SOX4 induces tumor invasion by targeting EMT-related pathway in prostate cancer.TUMOR BIOLOGY,39,(5)
MLA：
Liu, Yifan,et al."SOX4 induces tumor invasion by targeting EMT-related pathway in prostate cancer".TUMOR BIOLOGY 39..5(2017):-
