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Comparative clinical outcomes of Taiwanese patients with resected buccal and tongue squamous cell carcinomas

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机构： [1]Chang Gung Mem Hosp, Dept Otorhinolaryngol Head & Neck Surg, Taoyuan, Taiwan; [2]Chang Gung Univ, Taoyuan, Taiwan; [3]Chang Gung Univ, Clin Informat & Med Stat Res Ctr, Taoyuan, Taiwan; [4]Chang Gung Mem Hosp, Clin Trial Ctr, Biostat & Informat Unit, Taoyuan, Taiwan; [5]Chang Gung Mem Hosp, Dept Diagnost Radiol, Taoyuan, Taiwan; [6]Natl Hlth Res Inst, Natl Inst Canc Res, Miaoli, Taiwan; [7]Natl Cheng Kung Univ, Coll Med, Natl Cheng Kung Univ Hosp, Dept Otolaryngol, Tainan 701, Taiwan; [8]China Med Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Taichung, Taiwan; [9]Taichung Vet Gen Hosp, Dept Radiat Oncol, Taichung, Taiwan; [10]Hualien Tzu Chi Hosp, Dept Otolaryngol, Hualien, Taiwan; [11]Tzu Chi Univ, Hualien, Taiwan; [12]Natl Taiwan Univ Hosp, Dept Otolaryngol, Taipei, Taiwan; [13]Coll Med, Taipei, Taiwan; [14]Taipei Vet Gen Hosp, Dept Otolaryngol, Taipei, Taiwan; [15]E DA Hosp, Dept Otolaryngol, Kaohsiung, Taiwan; [16]I Shou Univ, Kaohsiung, Taiwan; [17]Mackay Mem Hosp, Dept Otolaryngol, Taipei, Taiwan; [18]Changhua Christian Hosp, Dept Oral & Maxillofacial Surg Head & Neck Surg, Changhua, Taiwan; [19]Koo Fdn Sun Yat Sen Canc Ctr, Dept Head & Neck Surg, Taipei, Taiwan; [20]Taipei Med Univ, Shuang Ho Hosp, Dept Otolaryngol, New Taipei City, Taiwan; [21]Chang Gung Mem Hosp, Dept Internal Med, Div Hematol Oncol, Keelung, Taiwan; [22]Chang Gung Univ, Coll Med, Kaohsiung Med Ctr, Chang Gung Mem Hosp,Dept Otolaryngol, Taoyuan, Taiwan; [23]Chang Gung Mem Hosp, Dept Radiat Oncol, Chiayi, Taiwan; [24]Chang Gung Mem Hosp, Dept Pathol, Taoyuan, Taiwan; [25]Chang Gung Mem Hosp, Dept Radiat Oncol, Taoyuan, Taiwan; [26]Chang Gung Mem Hosp, Dept Med Oncol, Taoyuan, Taiwan; [27]Chang Gung Mem Hosp, Dept Plast & Reconstruct Surg, Taoyuan, Taiwan; [28]Chang Gung Mem Hosp, Dept Nucl Med, Taoyuan, Taiwan; [29]Chang Gung Mem Hosp, Mol Imaging Ctr, Taoyuan, Taiwan; [30]Chang Gung Mem Hosp Linkou, Dept Nucl Med, 5 Fu Hsing St, Taoyuan, Taiwan

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关键词： Squamous cell carcinoma Buccal mucosa Tongue Prognosis Cancer Registry

摘要：

Objectives: Although patients with buccal squamous cell carcinoma (SCC) usually show acceptable outcomes, local control and survival rates are generally lower than those observed for tongue SCC. This study was designed to compare the clinical outcomes of Taiwanese patients with these two common oral cavity malignancies. Methods: Patients with first primary buccal or tongue SCC who were included in the Taiwanese Cancer Registry Database between 2004 and 2012 were eligible. The study sample consisted of 16,379 patients (7870 buccal SCC and 8509 tongue SCC) who received surgery with or without adjuvant therapy. The 5-year disease-specific survival (DSS) and overall survival (OS) rates served as the outcome measures. Results: Compared with tongue SCC, patients with buccal SCC had a higher prevalence of males (95.7% vs. 86.4%, p < 0.0001), pT4 disease (21.4% vs. 12.7%, p < 0.0001), and p-Stage IV (30.4% vs. 24.8%, p < 0.0001) but a lower frequency of pN2 disease (15.2% vs. 18.5%, p < 0.0001). The 5-year DSS and OS rates of buccal SCC patients were slightly higher than those of tongue SCC (78% vs. 77%, p = 0.0297; and 71% vs. 69%, = 0.0231, respectively). Multivariate analysis identified tumor site (tongue vs. buccal SCC), sex (male vs. female), age (>= 65 vs. <65 years), pT classification (T4/T3/T2 vs. T1), and pN classification (N3/N2/N1 vs. N0) as independent prognostic factors in the entire study cohort. Conclusions: The survival advantage of buccal SCC over tongue SCC appears significant in large clinical samples, despite a higher prevalence of p-Stage IV disease in the former. (C) 2017 Elsevier Ltd. All rights reserved.

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出版当年[2017]版：

大类 | 2 区

医学

小类 | 1 区牙科与口腔外科 3 区肿瘤学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区牙科与口腔外科 3 区肿瘤学

第一作者：

第一作者机构： [1]Chang Gung Mem Hosp, Dept Otorhinolaryngol Head & Neck Surg, Taoyuan, Taiwan; [2]Chang Gung Univ, Taoyuan, Taiwan;

通讯作者：

通讯机构： [2]Chang Gung Univ, Taoyuan, Taiwan; [28]Chang Gung Mem Hosp, Dept Nucl Med, Taoyuan, Taiwan; [29]Chang Gung Mem Hosp, Mol Imaging Ctr, Taoyuan, Taiwan; [30]Chang Gung Mem Hosp Linkou, Dept Nucl Med, 5 Fu Hsing St, Taoyuan, Taiwan

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Comparative clinical outcomes of Taiwanese patients with resected buccal and tongue squamous cell carcinomas

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