机构：[1]Montefiore Med Ctr, Albert Einstein Coll Med, Dept Oncol, Div Hematol, Bronx, NY 10467 USA;[2]Chinese Univ Hong Kong, Hong Kong Canc Inst, Partner State Key Lab Oncol South China, Sir YK Pao Ctr Canc,Dept Clin Oncol, Hong Kong, Hong Kong, Peoples R China;其他部门华南肿瘤学国家重点实验室中山大学肿瘤防治中心[3]Chinese Univ Hong Kong, Prince Wales Hosp, Hong Kong, Hong Kong, Peoples R China;[4]Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD USA;[5]Montefiore Med Ctr, Albert Einstein Coll Med, Dept Internal Med, Div Infect Dis, Bronx, NY 10467 USA;[6]Univ Hosp Case Med Ctr, Dept Hematol & Oncol, Cleveland, OH USA;[7]Chinese Univ Hong Kong, Dept Clin Oncol, Shatin, Hong Kong, Peoples R China
The significance of HIV associated paraproteins and their risk of progression to hematological malignancies remains unclear. We compared the development of hematological malignancies among HIV+ (n=266) and HIV- (n=537) patients with monoclonal gammopathies. HIV+ and HIV- patients with a positive serum protein electrophoresis test (SPEP) were studied. HIV+ SPEP+ were more likely to have faint and oligoclonal paraproteins (F-SPEP) and less likely to have discrete bands (D-SPEP) compared to HIV- SPEP+. The incidence of hematological malignancies was significantly lower in the HIV+ compared to the HIV- (6.4% vs 15.4%, p<0.0002). Upon subgroup analysis, the lower incidence of hematological malignancies was noted for HIV+ patients with F-SPEP but not for those with D-SPEP. Copyright (c) 2015 John Wiley & Sons, Ltd.
基金：
Einstein Montefiore Center for AIDS Research [NIH AI-051519]
语种：
外文
被引次数：
WOS：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区医学
小类|3 区血液学3 区肿瘤学
最新[2023]版：
大类|4 区医学
小类|4 区血液学4 区肿瘤学
第一作者：
第一作者机构：[1]Montefiore Med Ctr, Albert Einstein Coll Med, Dept Oncol, Div Hematol, Bronx, NY 10467 USA;
通讯作者：
通讯机构：[2]Chinese Univ Hong Kong, Hong Kong Canc Inst, Partner State Key Lab Oncol South China, Sir YK Pao Ctr Canc,Dept Clin Oncol, Hong Kong, Hong Kong, Peoples R China;[3]Chinese Univ Hong Kong, Prince Wales Hosp, Hong Kong, Hong Kong, Peoples R China;[7]Chinese Univ Hong Kong, Dept Clin Oncol, Shatin, Hong Kong, Peoples R China
推荐引用方式(GB/T 7714)：
Jou Erin,Gligich Oleg,Chan Alvita C. Y.,et al.Retrospective study of the prevalence and progression of monoclonal gammopathy in HIV positive versus HIV negative patients[J].HEMATOLOGICAL ONCOLOGY.2017,35(1):64-68.doi:10.1002/hon.2247.
APA：
Jou, Erin,Gligich, Oleg,Chan, Alvita C. Y.,Mohan, Diwakar,Felsen, Uriel R....&Raghupathy, Radha.(2017).Retrospective study of the prevalence and progression of monoclonal gammopathy in HIV positive versus HIV negative patients.HEMATOLOGICAL ONCOLOGY,35,(1)
MLA：
Jou, Erin,et al."Retrospective study of the prevalence and progression of monoclonal gammopathy in HIV positive versus HIV negative patients".HEMATOLOGICAL ONCOLOGY 35..1(2017):64-68
