Background: Pilocytic astrocytomas (PAs) are slow growing neoplasms and usually located at the cerebellum. There has been certainty regarding the truthful benefit of surgical resection for patients with PA. Gross total resection (GTR) of PAs, especially those being situated in deep regions, remains a surgical challenge. Generally, they are considered as benign and usually develop in young patients. PAs, belonging to WHO I can be cured by radical resection. The patients with PA have excellent prognosis if complete resection can be conducted. The use of fluorescein in vermis PA surgery has not been yet reported. Our data presents fluorescein facilitates surgical resection of vermis PA. Methods: Five milligrams per kilogram of fluorescein sodium was intravenously injected directly before general anesthesia for the three patients with PA. The yellow 560 filter was employed for microsurgical tumor resection. Surgical outcomes were assessed concerning the extent of resection. Results: Most portion of PA in the three cases was found to be highly fluorescent after intravenous fluorescein sodium injection, which markedly enhanced tumor visibility. Gross total resection in all of the patients was achieved without further neurological deficits. No adverse effects and complications resulting from fluorescein sodium were observed over the postoperative course. Conclusions: Intraoperative guidance by fluorescein sodium as a new, simple, safe, and practical procedure can enhance the fidelity of tumor tissue and increase the possibility of completely resecting PAs.
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外文
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出版当年[2017]版:
大类|4 区医学
小类|4 区肿瘤学4 区外科
最新[2023]版:
大类|3 区医学
小类|3 区肿瘤学3 区外科
第一作者:
第一作者机构:[1]Sun Yat Sen Univ, State Key Lab Oncol South China, Ctr Canc Med, Dept Neurosurg,Canc Ctr,Collaborat Innovat, 651 Dong Feng East Rd, Guangzhou 510060, Guangdong, Peoples R China;
通讯作者:
通讯机构:[1]Sun Yat Sen Univ, State Key Lab Oncol South China, Ctr Canc Med, Dept Neurosurg,Canc Ctr,Collaborat Innovat, 651 Dong Feng East Rd, Guangzhou 510060, Guangdong, Peoples R China;
推荐引用方式(GB/T 7714):
Zhang Ji,Al-Nahari Fuad,Wang Zi-feng,et al.Application of fluorescein sodium in the resection of vermis pilocytic astrocytomas[J].WORLD JOURNAL OF SURGICAL ONCOLOGY.2017,15(1):9-13.doi:10.1186/s12957-017-1108-5.
APA:
Zhang, Ji,Al-Nahari, Fuad,Wang, Zi-feng,Lin, Fu-hua,Zhao, Yi-yin...&Mou, Yong-gao.(2017).Application of fluorescein sodium in the resection of vermis pilocytic astrocytomas.WORLD JOURNAL OF SURGICAL ONCOLOGY,15,(1)
MLA:
Zhang, Ji,et al."Application of fluorescein sodium in the resection of vermis pilocytic astrocytomas".WORLD JOURNAL OF SURGICAL ONCOLOGY 15..1(2017):9-13