Background: This study aimmed to evaluate the expression of p53-inducible RR small subunit 2 homologue (p53R2) in Lung sarcomatoid carcinoma (LSC) and its association with clinicopathological parameters and prognosis. Methods: In this study, clinicopathological factors and prognostic significance of the expression of p53R2 was investigated by immunohistochemistry (IHC) in 100 cases of LSC. Results: The results showed that the expression of p53R2 was significantly correlated with clinical stage (P<0.05). But there was no statistically correlation with gender, age, smoking, tumor size, pT stage, pN stage, pM stage, therapy and relapse. Kaplan-Meier analysis revealed that the expression of p53R2, clinical stage, pT stage, pN stage, pM stage and tumor size were closely related to patients' survival, and the analysis also revealed that patients with low expression of p53R2 had a longer overall survival than that with high expression (Mean overall survival: 84.8 months vs. 34.7 months, P<0.05). Further multivariate analysis indicated that the expression of p53R2 was identified as an independent prognostic factor in the prediction of the overall survival for patients with LSC (HR = 3.217, P<0.05). Conclusions: The expression of p53R2 was inversely associated with the proliferation and progression of LSC, and the results indicated that the high expression of p53R2 was an independent factor for unfavorable prognosis of patients with LSC.
基金：
Nature Science Foundation of ChinaNational Natural Science Foundation of China [81602233]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区医学
小类|3 区肿瘤学
最新[2023]版：
大类|2 区医学
小类|3 区肿瘤学
第一作者：
第一作者机构：[1]Sun Yat Sen Univ, Dept Pathol, Ctr Canc, Guangzhou 510060, Guangdong, Peoples R China;[3]Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Ctr Canc, Guangzhou, Guangdong, Peoples R China
通讯作者：
通讯机构：[1]Sun Yat Sen Univ, Dept Pathol, Ctr Canc, Guangzhou 510060, Guangdong, Peoples R China;[3]Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Ctr Canc, Guangzhou, Guangdong, Peoples R China
推荐引用方式(GB/T 7714)：
Chen Jiewei,Xiao Yongbo,Cai Xiaoyan,et al.Overexpression of p53R2 is associated with poor prognosis in lung sarcomatoid carcinoma[J].BMC CANCER.2017,17(1):-.doi:10.1186/s12885-017-3811-6.
APA：
Chen, Jiewei,Xiao, Yongbo,Cai, Xiaoyan,Liu, Jun,Chen, Keming&Zhang, Xinke.(2017).Overexpression of p53R2 is associated with poor prognosis in lung sarcomatoid carcinoma.BMC CANCER,17,(1)
MLA：
Chen, Jiewei,et al."Overexpression of p53R2 is associated with poor prognosis in lung sarcomatoid carcinoma".BMC CANCER 17..1(2017):-
医学