F-box proteins play pivotal roles in multiple cellular processes; however, little is known about their functions in glioma progression. In this study, we found that expression of the F-box and leucine-rich repeat protein 18 (FBXL18) is significantly upregulated in glioma tissues. Depletion of FBXL18 in glioma cells suppresses proliferation and anchorage-independent cell growth, and promotes apoptosis. We also demonstrate that depletion of FBXL18 significantly inhibits Akt activity and the phosphorylation of FOXO3a, which leads to upregulation of BCL2L11. Further mechanistic analyses indicate that FBXL18 promotes the K63-linked ubiquitination of Akt, which is required for its activation. Taken together, our results suggest that FBXL18 plays an oncogenic role through promoting K63-linked ubiquitination of Akt in glioma.
基金：
National Key Basic Research Program of ChinaNational Basic Research Program of China [2015CB859800, 2014CB910800]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [31370869, 31522018, 81302197, 31071046]; Guangdong Natural Science Funds for Distinguished Young Scholar [S2013050014772]; Guangdong Innovative Research Team Program [2011Y035]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [15lgjc02]; Jiangsu Provincial Special Programme of Medical Science [BL2014035]; Changzhou Science Development Project [CE20155060, CE20165048]; Changzhou High-Level Medical Talents Training Project [2016CZBJ006]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|2 区生物
小类|2 区生物物理3 区生化与分子生物学3 区细胞生物学
最新[2023]版：
大类|4 区生物学
小类|4 区生化与分子生物学4 区生物物理4 区细胞生物学
第一作者：
第一作者机构：[1]Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, Guangzhou, Guangdong, Peoples R China;[2]Sun Yat Sen Univ, Zhongshan Sch Med, Guangzhou, Guangdong, Peoples R China;[3]Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou, Guangdong, Peoples R China;
通讯作者：
通讯机构：[1]Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, Guangzhou, Guangdong, Peoples R China;[5]Soochow Univ, Affiliated Hosp 3, Modern Med Res Ctr, 185 Juqian Rd, Changzhou 213000, Jiangsu, Peoples R China;[6]Sun Yat Sen Univ, Sch Life Sci, Key Lab Gene Engn, Minist Educ,State Key Lab Biocontrol, Eastern Campus,Rm320,Bldg Sch Life Sci, Guangzhou 510006, Guangdong, Peoples R China
推荐引用方式(GB/T 7714)：
Zhang Jindong,Yang Zhifen,Ou Jiayu,et al.The F-box protein FBXL18 promotes glioma progression by promoting K63-linked ubiquitination of Akt[J].FEBS LETTERS.2017,591(1):145-154.doi:10.1002/1873-3468.12521.
APA：
Zhang, Jindong,Yang, Zhifen,Ou, Jiayu,Xia, Xiaojun,Zhi, Feng&Cui, Jun.(2017).The F-box protein FBXL18 promotes glioma progression by promoting K63-linked ubiquitination of Akt.FEBS LETTERS,591,(1)
MLA：
Zhang, Jindong,et al."The F-box protein FBXL18 promotes glioma progression by promoting K63-linked ubiquitination of Akt".FEBS LETTERS 591..1(2017):145-154
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