Tetherin (BST2/ CD317) is an interferon-inducible antiviral factor known for its ability to block the release of enveloped viruses from infected cells. Yet its role in type I interferon (IFN) signaling remains poorly defined. Here, we demonstrate that Tetherin is a negative regulator of RIG-I like receptor (RLR)mediated type I IFN signaling by targeting MAVS. The induction of Tetherin by type I IFN accelerates MAVS degradation via ubiquitin-dependent selective autophagy in human cells. Moreover, Tetherin recruits E3 ubiquitin ligase MARCH8 to catalyze K27-linked ubiquitin chains on MAVS at lysine 7, which serves as a recognition signal for NDP52dependent autophagic degradation. Taken together, our findings reveal a negative feedback loop of RLR signaling generated by Tetherin-MARCH8MAVS-NDP52 axis and provide insights into a better understanding of the crosstalk between selective autophagy and optimal deactivation of type I IFN signaling.
基金：
National Key Basic Research Program of ChinaNational Basic Research Program of China [2015CB859800]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [31522018, 91629101, 31700760]; Guangdong Natural Science Funds for Distinguished Young Scholar [S2013050014772]; Guangdong Innovative Research Team Program [2011Y035]; Guangzhou Science and Technology Project [201605030012]
语种：
外文
被引次数：
WOS：
中科院(CAS)分区：
出版当年[2017]版：
大类|1 区生物
小类|1 区生化与分子生物学1 区细胞生物学
最新[2023]版：
大类|1 区生物学
小类|1 区生化与分子生物学1 区细胞生物学
第一作者：
第一作者机构：[1]Sun Yat Sen Univ, Key Lab Gene Engn, Minist Educ, State Key Lab Biocontrol,Sch Life Sci, Guangzhou 510275, Guangdong, Peoples R China;
通讯作者：
通讯机构：[1]Sun Yat Sen Univ, Key Lab Gene Engn, Minist Educ, State Key Lab Biocontrol,Sch Life Sci, Guangzhou 510275, Guangdong, Peoples R China;[2]Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, Guangzhou 510006, Guangdong, Peoples R China
推荐引用方式(GB/T 7714)：
Jin Shouheng,Tian Shuo,Luo Man,et al.Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells[J].MOLECULAR CELL.2017,68(2):308-+.doi:10.1016/j.molcel.2017.09.005.
APA：
Jin, Shouheng,Tian, Shuo,Luo, Man,Xie, Weihong,Liu, Tao...&Cui, Jun.(2017).Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells.MOLECULAR CELL,68,(2)
MLA：
Jin, Shouheng,et al."Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells".MOLECULAR CELL 68..2(2017):308-+
生物