机构：[1]Department of Anesthesiology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou 510060, China临床科室其他部门手术麻醉科华南肿瘤学国家重点实验室中山大学肿瘤防治中心[2]Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China[3]Department of Nephrology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China内科科室肾内科广东省人民医院[4]Department of Clinical Trial Center, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou 510060, China其他部门华南肿瘤学国家重点实验室中山大学肿瘤防治中心
The main hallmarks of Alzheimer's disease (AD) are extracellular deposits of amyloid plaques and intracellular accumulation of hyperphosphorylated neurofibrillary tangles (tau). However, the mechanisms underlying these neuropathological changes remain largely unclear. To date, plenty of studies have shown that microglia-mediated neuroinflammation contributes to the pathogenesis of AD, and the microglia-synapse pathways have been repeatedly identified as the crucial factor in the disease process. In this review, evidences from microglia and synapse studies are presented, and the role of microglia in the pathogenesis of AD, the contributing factors to synapse dysfunction, and the role and mechanisms of microglia-synapse pathways will be discussed.
基金：
Natural Science Foundation of Guangdong Province, China [2015A030310038, 2014A030310106]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区生物
小类|3 区生物工程与应用微生物4 区医学：研究与实验
最新[2025]版：
大类|4 区医学
小类|4 区生物工程与应用微生物4 区医学：研究与实验
第一作者：
第一作者机构：[1]Department of Anesthesiology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou 510060, China
共同第一作者：
通讯作者：
通讯机构：[3]Department of Nephrology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China[4]Department of Clinical Trial Center, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou 510060, China
推荐引用方式(GB/T 7714)：
Xie Jingdun,Wang Haitao,Lin Ting,et al.Microglia-Synapse Pathways: Promising Therapeutic Strategy for Alzheimer's Disease[J].BIOMED RESEARCH INTERNATIONAL.2017,2017:-.doi:10.1155/2017/2986460.
APA：
Xie, Jingdun,Wang, Haitao,Lin, Ting&Bi, Bingtian.(2017).Microglia-Synapse Pathways: Promising Therapeutic Strategy for Alzheimer's Disease.BIOMED RESEARCH INTERNATIONAL,2017,
MLA：
Xie, Jingdun,et al."Microglia-Synapse Pathways: Promising Therapeutic Strategy for Alzheimer's Disease".BIOMED RESEARCH INTERNATIONAL 2017.(2017):-
