机构：[1]College of Chemistry, Sichuan University, Chengdu 610064, China[2]Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China[3]Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China
Copper-64 is a useful radioisotope for positron emission tomography (PET). Due to the wide range of applications, the demand of 64Cu with low metallic impurities is increasing. Here we report a simple method for the efficient production of high specific activity 64Cu using a cyclotron for biomedical application. We designed new equipment based on the plating of enriched 64Ni as the target, and used automated ion exchange chromatography to purify copper-64 efficiently after irradiation and dissolution of the target in good radiochemical and chemical yield and purity. The 64Cu radionuclide produced using 99.32% enriched 64Ni with a density of 61.4 ± 5.0 mg/cm², reaching a total radioactivity greater than 200 mCi, with specific activity up to 5.6 GBq/μmoL. It was further incorporated into modified monoclonal antibody DOTA-rituximab to synthesize 64Cu-DOTA-rituximab, which was used successfully for micro-PET imaging.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区化学
小类|3 区有机化学
最新[2023]版：
大类|2 区化学
小类|3 区生化与分子生物学3 区化学：综合
第一作者：
第一作者机构：[1]College of Chemistry, Sichuan University, Chengdu 610064, China[2]Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China
共同第一作者：
通讯作者：
通讯机构：[1]College of Chemistry, Sichuan University, Chengdu 610064, China[2]Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China
推荐引用方式(GB/T 7714)：
Xie Qinghua,Zhu Hua,Wang Feng,et al.Establishing Reliable Cu-64 Production Process: From Target Plating to Molecular Specific Tumor Micro-PET Imaging.[J].MOLECULES.2017,22(4):doi:10.3390/molecules22040641.
APA：
Xie Qinghua,Zhu Hua,Wang Feng,Meng Xiangxi,Ren Qiushi...&Yang Zhi.(2017).Establishing Reliable Cu-64 Production Process: From Target Plating to Molecular Specific Tumor Micro-PET Imaging..MOLECULES,22,(4)
MLA：
Xie Qinghua,et al."Establishing Reliable Cu-64 Production Process: From Target Plating to Molecular Specific Tumor Micro-PET Imaging.".MOLECULES 22..4(2017)
