机构：[1]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, PR China[2]Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, PR China[3]Department of Urology, Institute of Urology, Laboratory of Reconstructive Urology, West China Hospital, Sichuan University, Chengdu 610041, PR China
The prognostic role of vascular endothelial growth factor (VEGF) in cervical cancer is controversial to date. The aim of this study was to evaluate the prognostic value of VEGF and VEGF-C in patients with cervical cancer. Relevant studies were identified by systematic search of the PubMed and Embase database. The primary data of eligible studies was hazard ratio (HR) with 95% confidence interval (95% CI) of survival outcomes, including overall survival (OS), disease-free survival (DFS) and progression-free survival (PFS). Pooled HR (95% CI) was calculated to evaluate the prognostic role of VEGF and VEGF-C in cervical cancer patients. The methodological qualities of the included studies were assessed using REMARK. Fourteen eligible articles including 1306 patients were included in the meta-analysis. The pooled HRs (95% CIs) of VEGF for OS and DFS/PFS were 2.29 [1.27, 4.14] and 2.77 [1.37, 5.62], respectively. The HR (95% CI) of VEGF-C for OS was 3.94 [2.22, 6.99]. This meta-analysis suggested that high expressions of VEGF and VEGF-C were significantly associated with poor survival outcome in cervical cancer patients.
基金：
Administration of Traditional Chinese Medicine of Sichuan [2014K158]; Science and Technology Administration, Sichuan Province [2017SZ0048, 2014SZ0031]; Health and Family Planning Commission of Sichuan Province [16PJ298]; Science and Technology Administration, Chengdu [2015-RK00-00233-ZF]
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|2 区医学
小类|2 区肿瘤学3 区细胞生物学
最新[2023]版：
无
第一作者：
第一作者机构：[1]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, PR China[2]Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, PR China
共同第一作者：
通讯作者：
通讯机构：[1]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, PR China
推荐引用方式(GB/T 7714)：
Zhang Jing,Liu Jiaming,Zhu Chenjing,et al.Prognostic role of vascular endothelial growth factor in cervical cancer: a meta-analysis.[J].Oncotarget.2017,8(15):24797-24803.doi:10.18632/oncotarget.15044.
APA：
Zhang Jing,Liu Jiaming,Zhu Chenjing,He Jialing,Chen Jinna...&Ma Xuelei.(2017).Prognostic role of vascular endothelial growth factor in cervical cancer: a meta-analysis..Oncotarget,8,(15)
MLA：
Zhang Jing,et al."Prognostic role of vascular endothelial growth factor in cervical cancer: a meta-analysis.".Oncotarget 8..15(2017):24797-24803
