机构：[1]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and National Collaborative Innovation Center for Biotherapy, No. 17, 3rd Section of People’s South Road, Chengdu 610041, People’s Republic of China[2]Department of Urinary Surgery, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, People’s Republic of China[3]Laboratory of Cell andMolecular Biology&State Key Laboratory of Molecular Oncology, Cancer Institute & Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100034, People’s Republic of China
Clinical microbial identification plays an important role in optimizing the management of infectious diseases and provides diagnostic and therapeutic support for clinical management. Microbial proteomic research is aimed at identifying proteins associated with microbial activity, which has facilitated the discovery of microbial physiology changes and host-pathogen interactions during bacterial infection and antimicrobial therapy. Here, we summarize proteomic-driven progresses of host-microbial pathogen interactions at multiple levels, mass spectrometry-based microbial proteome identification for clinical diagnosis, and antimicrobial therapy. Proteomic technique progresses pave new ways towards effective prevention and drug discovery for microbial-induced infectious diseases.
基金：
National Key Basic Research Program of ChinaNational Basic Research Program of China [2013CB911303]; National 863 High Tech FoundationNational High Technology Research and Development Program of China [2014AA020608]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [31470810, 31071235]
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区医学
小类|3 区传染病学3 区微生物学
最新[2023]版：
大类|3 区医学
小类|3 区传染病学3 区微生物学
第一作者：
第一作者机构：[1]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and National Collaborative Innovation Center for Biotherapy, No. 17, 3rd Section of People’s South Road, Chengdu 610041, People’s Republic of China
通讯作者：
通讯机构：[1]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and National Collaborative Innovation Center for Biotherapy, No. 17, 3rd Section of People’s South Road, Chengdu 610041, People’s Republic of China
推荐引用方式(GB/T 7714)：
Chen B,Zhang D,Wang X,et al.Proteomics progresses in microbial physiology and clinical antimicrobial therapy.[J].EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES.2017,36(3):403-413.doi:10.1007/s10096-016-2816-4.
APA：
Chen B,Zhang D,Wang X,Ma W,Deng S...&Liang S.(2017).Proteomics progresses in microbial physiology and clinical antimicrobial therapy..EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES,36,(3)
MLA：
Chen B,et al."Proteomics progresses in microbial physiology and clinical antimicrobial therapy.".EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES 36..3(2017):403-413
