机构：[1]Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Chengdu, China[2]Chongqing Cancer Institute & Hospital & Cancer Center, Chongqing, China
The gene polymorphism of interleukin-6 (IL-6) has been shown to be implicated in tuberculosis susceptibility in many studies, but with conflicting results. This study aimed to provide more accurate estimation of the relationship between IL-6 gene polymorphism and tuberculosis risk through a meta-analysis.
A literature search was performed in PubMed, EMBASE, and other databases. Data were retrieved, and pooled odds ratio (OR) with 95% CI were calculated. Statistical analyses were performed by using STATA 12.0.
Twelve publications with 2635 cases and 3049 controls were included. The pooled analysis demonstrated significant evidence of association between IL-6 (-174G/C) and low risk of tuberculosis in dominant model (CC+GC vs GG: OR =0.693, 95% CI 0.581-0.826, p<0.001). Subgroup analysis got similar results for IL-6 (-174G/C) in Asians and Latinos, but the significance did not exist in Caucasians. IL-6 (-572C/G) polymorphism was also associated with low risk of tuberculosis in dominant model (CC+GC vs GG: OR =0.719, 95% CI 0.577-0.896, p=0.003). No publication bias was detected in either of the polymorphisms.
In summary, IL-6 -572 C/G polymorphism may be associated with a decreased risk of tuberculosis, and C allele is the protective factor against tuberculosis for IL-6 -174G/C among Asians and Latinos, but not in Caucasian population.
基金：
National Scientific and Technological Major Project of China [2012ZX10004-901]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81230001, 81470236]
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|2 区医学
小类|2 区传染病学2 区药学
最新[2023]版：
大类|3 区医学
小类|3 区传染病学3 区药学
第一作者：
第一作者机构：[1]Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Chengdu, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Chengdu, China[*1]Fuqiang Wen Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, No. 37, Guoxuexiang, Chengdu, Sichuan 610041, China
推荐引用方式(GB/T 7714)：
Wang Hao,Pang Caishuang,Zeng Ni,et al.Association between the IL-6 gene polymorphism and tuberculosis risk: a meta-analysis.[J].Infection and drug resistance.2017,10:445-454.doi:10.2147/IDR.S144296.
APA：
Wang Hao,Pang Caishuang,Zeng Ni,Wan Chun,Shen Yongchun&Wen Fuqiang.(2017).Association between the IL-6 gene polymorphism and tuberculosis risk: a meta-analysis..Infection and drug resistance,10,
MLA：
Wang Hao,et al."Association between the IL-6 gene polymorphism and tuberculosis risk: a meta-analysis.".Infection and drug resistance 10.(2017):445-454
