Feasibility and Efficacy of Microwave Ablation Combined with Iodine-125 Seed Implantation in Local Control of Recurrent Retroperitoneal Liposarcomas: Initial Clinical Experience
机构：[a]Department of Interventional Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, P.R. China医学影像科其他科室肿瘤介入科肿瘤科中山大学附属第一医院[b]Department of Medical Imaging & Interventional Radiology, Guangzhou Women and Children’s Medical Center, Guangzhou, P.R. China[c]Department of Medical Imaging & Interventional Radiology, Cancer Center and State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou, P.R. China临床科室其他部门放疗科影像科华南肿瘤学国家重点实验室中山大学肿瘤防治中心
Introduction. The objective of the present study was to evaluate the feasibility, safety, and short-term efficacy of microwave ablation (MWA) combined with iodine-125 (I-125) seed implantation in recurrent retroperitoneal liposarcomas (rRPLs). Materials and Methods. From September 2012 to March 2015, 11 patients were enrolled in this prospective study. Eleven tumors (median, 9 cm; range, 5.5-12.5 cm) were treated with computerized tomography-guided MWA for 11 sessions and I-125 seed implantation for 18 sessions. I-125 seed implantation was performed 4 weeks after MWA. Results. There were no procedure-related deaths. Post-MWA pain (grade >= 2) was the most common complication (6 of 11 patients, 54.5%), and fever (grade >= 2) was observed in two patients. Reversible nerve injury, defined as transient limb paresthesia or leg weakness, was observed in one patient. There were fewer complications associated with the I-125 seed implantation procedure compared with the MWA procedure. All 11 patients who underwent the MWA procedure achieved a partial response (PR), according to the modified Response Evaluation Criteria in Solid Tumors, 1 month post-ablation; after I-125 seed implantation was performed, a complete response was observed in three, five, and six target tumors in 3, 6, and 12 months, respectively. Conclusion. In selected patients with rRPLs, MWA combined with I-125 seed implantation is feasible and safe with favorable local control efficacy.
基金：
National Natural Science Foundation of China (NSFC) [81371654]
语种：
外文
被引次数：
WOS：
中科院(CAS)分区：
出版当年[2017]版：
大类|2 区医学
小类|2 区肿瘤学
最新[2023]版：
大类|2 区医学
小类|2 区肿瘤学
第一作者：
第一作者机构：[a]Department of Interventional Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, P.R. China
共同第一作者：
通讯作者：
通讯机构：[a]Department of Interventional Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, P.R. China[c]Department of Medical Imaging & Interventional Radiology, Cancer Center and State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou, P.R. China[*1]Department of Medical Imaging & Interventional Radiology, Cancer Center and State Key Laboratory of Oncology in South China, Sun Yat-sen University, 651 Dongfeng Road, East, Guangzhou, 510060, P.R. China[*2]Department of Interventional Oncology, The First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan Road II Guangzhou, 510080, P.R. China
推荐引用方式(GB/T 7714)：
MINGJIAN LU,WANG YAO ,TAO ZHANG ,et al.Feasibility and Efficacy of Microwave Ablation Combined with Iodine-125 Seed Implantation in Local Control of Recurrent Retroperitoneal Liposarcomas: Initial Clinical Experience[J].ONCOLOGIST.2017,22(12):1500-1505.doi:10.1634/theoncologist.2016-0499.
APA：
MINGJIAN LU,WANG YAO,,TAO ZHANG,,WENZHE FAN,,ZHIHUI ZHONG,...&FUJUN ZHANG.(2017).Feasibility and Efficacy of Microwave Ablation Combined with Iodine-125 Seed Implantation in Local Control of Recurrent Retroperitoneal Liposarcomas: Initial Clinical Experience.ONCOLOGIST,22,(12)
MLA：
MINGJIAN LU,et al."Feasibility and Efficacy of Microwave Ablation Combined with Iodine-125 Seed Implantation in Local Control of Recurrent Retroperitoneal Liposarcomas: Initial Clinical Experience".ONCOLOGIST 22..12(2017):1500-1505
医学