机构：[1]Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.[2]State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou, China.其他部门华南肿瘤学国家重点实验室中山大学肿瘤防治中心[3]Department of Pathology, Cancer Center, Sun Yat-Sen University, Guangzhou, China.[4]Department of Oncology, The first Affiliated Hospital, Sun Yat-Sen University, No.58, Zhongshan Second Road, 510080 Guangzhou, China.其他科室肿瘤科中山大学附属第一医院
Background: The telomerase/telomere interacting protein PinX1 has been suggested as a tumor suppressor. However, the clinical and biological significance of PinX1 in human non-small cell lung cancer (NSCLC) is unclear. Methods: PinX1 gene/expression pattern and its association with NSCLC patient survival were analyzed in cBioportal Web resource and two cohorts of NSCLC samples. A series of in vivo and in vitro assays were performed to elucidate the function of PinX1 on NSCLC cells proliferation and underlying mechanisms. Results: More frequency of gene PinX1 homozygous deletion and heterozygote deficiency was first retrieved from cBioportal Web resource. Low expression of PinX1 correlated with smoking condition, histological type, T stage, N stage, M stage and TNM stage, and was an independent predictor for overall survival in a learning cohort (n = 93) and a validation cohort (n = 51) of NSCLC patients. Furthermore, knockdown of PinX1 dramatically accelerated NSCLC cell proliferation and G1/S transition, whereas ectopic overexpression of PinX1 substantially inhibited cell viability and cell cycle transition in vitro and in vivo. p15/cyclin D1 pathway and BMP5 might contribute to PinX1associated cell proliferation and cell cycle transition. Conclusion: The cost-effective expression of PinX1 could constitute a novel molecular predictor/marker for NSCLC management.
基金：
This study was supported by Research grants from the 973 Project of China
(No. 2010CB912802) and the National Nature Science Foundation of China
(No. 81603137).
语种：
外文
被引次数：
WOS：
中科院(CAS)分区：
出版当年[2017]版：
大类|2 区医学
小类|2 区生化与分子生物学2 区肿瘤学
最新[2023]版：
大类|1 区医学
小类|1 区生化与分子生物学1 区肿瘤学
第一作者：
第一作者机构：[1]Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.[2]State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou, China.
共同第一作者：
通讯作者：
通讯机构：[1]Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.[4]Department of Oncology, The first Affiliated Hospital, Sun Yat-Sen University, No.58, Zhongshan Second Road, 510080 Guangzhou, China.
推荐引用方式(GB/T 7714)：
Xiao-Peng Tian,Xiao-Han Jin,Mei Li,et al.The depletion of PinX1 involved in the tumorigenesis of non-small cell lung cancer promotes cell proliferation via p15/cyclin D1 pathway[J].MOLECULAR CANCER.2017,16(1):-.doi:10.1186/s12943-017-0637-4.
APA：
Xiao-Peng Tian,Xiao-Han Jin,Mei Li,Wei-Juan Huang,Dan Xie&Jia-Xing Zhang.(2017).The depletion of PinX1 involved in the tumorigenesis of non-small cell lung cancer promotes cell proliferation via p15/cyclin D1 pathway.MOLECULAR CANCER,16,(1)
MLA：
Xiao-Peng Tian,et al."The depletion of PinX1 involved in the tumorigenesis of non-small cell lung cancer promotes cell proliferation via p15/cyclin D1 pathway".MOLECULAR CANCER 16..1(2017):-
医学