机构：[a]Department of Urology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, China外科科室泌尿外科中山大学附属第一医院[b]Department of Urology, Jiangmen Central Hospital, Jiangmen, Guangdong 529030, China[c]Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, China临床科室泌尿外科中山大学肿瘤防治中心
AIM: This study aimed to investigate the methylation status of EGF-like and two follistatin-like domains 2 (TMEFF2) promoter and its correlation with tumor stage and survival outcome in renal cell carcinoma (RCC). MATERIALS AND METHODS: Paraffin-embedded specimens from 42 RCC patients were analyzed for TMEFF2 methylation by methylation-specific polymerase chain reaction. The distribution of TNM/AJCC stages and survival time were compared among patients with unmethylated and methylated TMEFF2. RESULTS: There were 25 (59.5%) and 17 (40.5%) cases with methylated (M group) and unmethylated (M group) TMEFF2, respectively. There were more early-stage cancer patients in U group than in M group. Kaplan-Meier survival analysis showed that U group had a better but not significant survival outcome than M group (P = 0.123). CONCLUSION: These findings showed that TMEFF2 methylation is not rare in RCC, and methylation may play an important role in the tumorigenesis of ccRCC.
基金：
Science and Technology Foundation of Guangzhou [2014A020212580]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|4 区医学
小类|4 区肿瘤学
最新[2023]版：
大类|4 区医学
小类|4 区肿瘤学
第一作者：
第一作者机构：[a]Department of Urology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, China
共同第一作者：
通讯作者：
通讯机构：[a]Department of Urology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, China[*]Department of Urology, The First Affiliated Hospital of Sun Yat-sen University, No. 58, Zhongshan Second Road, Yuexiu District, Guangzhou, Guangdong 510080, China.
推荐引用方式(GB/T 7714)：
Enjing Chen,Fufu Zheng,Xiaoxu Yuan,et al.The effect of TMEFF2 methylation on the tumor stage and survival outcome of clear cell renal cell carcinoma[J].CANCER BIOMARKERS.2017,19(2):207-212.doi:10.3233/CBM-161656.
APA：
Enjing Chen,Fufu Zheng,Xiaoxu Yuan,Yunlin Ye,Xiaofei Li...&Lingwu Chen.(2017).The effect of TMEFF2 methylation on the tumor stage and survival outcome of clear cell renal cell carcinoma.CANCER BIOMARKERS,19,(2)
MLA：
Enjing Chen,et al."The effect of TMEFF2 methylation on the tumor stage and survival outcome of clear cell renal cell carcinoma".CANCER BIOMARKERS 19..2(2017):207-212
