个人中心| | 帮助
高级检索
当前位置： 首页 > 详情页

A thermo-sensitive hydrogel targeting macrophage reprogramming for sustained osteoarthritis pain relief

| 认领 | 导出 | |

文献详情

资源类型：
Pubmed体系：

收录情况： ◇ 统计源期刊 ◇ CSCD-C ◇ 卓越：领军期刊

作者：
Liu Yue[1,2] * ; Zhou Kai[3,4] * ; He Xinlong[3] ; Shi Kun[3] ; Hu Danrong[3] ; Yang Chenli[3] ; Peng Jinrong[3] ; He Yuqi[5] ; Zhao Guoyan[5] ; Kang Yi[5] ; Zhang Yujun[1,5] ; Dai Yue'e[2] ; Zeng Min[6] ; Xian Feier[6] ; Zhang Wensheng[1,5] ; Qian Zhiyong[3] ;
机构： [1]Department of Anaesthesiology, West China Hospital, Sichuan University, Chengdu 610041, China. [2]Department of Anaesthesiology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China. [3]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China. [4]Department of Orthopedics and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610041, China. [5]Laboratory of Anaesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anaesthesiology, West China Hospital, Sichuan University, Chengdu 610041, China. [6]West China School of Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
出处：
DOI： 10.1016/j.apsb.2025.07.024
ISSN：

关键词： Chronic pain Dorsal root ganglion Macrophages Osteoarthritis Thermo-sensitive hydrogel Neuroinflammation Drug delivery Pain management

摘要：
Osteoarthritis (OA) causes chronic pain that significantly impairs quality of life, with current treatments often proving insufficient and accompanied by adverse effects. Recent research has identified the dorsal root ganglion (DRG) and its resident macrophages as crucial mediators of chronic OA pain through neuroinflammation driven by macrophage polarization. We present a novel injectable thermo-sensitive hydrogel system, KAF@PLEL, designed to deliver an anti-inflammatory peptide (KAF) specifically to the DRG. This biodegradable hydrogel enables sustained KAF release, promoting the reprogramming of DRG macrophages from pro-inflammatory to anti-inflammatory phenotypes. Through comprehensive in vitro and in vivo studies, we evaluated the hydrogel's biocompatibility, effects on macrophage polarization, and therapeutic efficacy in chronic OA pain management. The system demonstrated significant capabilities in preserving macrophage mitochondrial function, suppressing neuroinflammation, alleviating chronic OA pain, reducing cartilage degradation, and improving motor function in OA rat models. The sustained-release properties of KAF@PLEL enabled prolonged therapeutic effects while minimizing systemic exposure and side effects. These findings suggest that KAF@PLEL represents a promising therapeutic approach for improving outcomes in OA patients through targeted, sustained treatment.© 2025 The Authors.

基金：
This work was financially supported by the National Natural Science Foundation of China (Nos. U21A20417, 31930067, 82002304, 82301412, 82401456), The 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University, China (No. ZYJC21068, China), Sichuan Provincial Health Research Projects (No. 2025-111, China), The Young Talents Project of Sichuan Provincial People’s Hospital (No. 2022QN50, China), The cadres health research topic Sichuan Province (No. 2023-217, China), The Sichuan Science and Technology Program (No. 2022YFS0439, China).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类 | 1 区 医学
小类 | 1 区 药学
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 药学
第一作者：
第一作者机构： [1]Department of Anaesthesiology, West China Hospital, Sichuan University, Chengdu 610041, China. [2]Department of Anaesthesiology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Anaesthesiology, West China Hospital, Sichuan University, Chengdu 610041, China. [5]Laboratory of Anaesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anaesthesiology, West China Hospital, Sichuan University, Chengdu 610041, China.
推荐引用方式(GB/T 7714)：
Liu Yue,Zhou Kai,He Xinlong,et al.A thermo-sensitive hydrogel targeting macrophage reprogramming for sustained osteoarthritis pain relief[J].Acta Pharmaceutica Sinica B.2025,15(11):6034-6051.doi:10.1016/j.apsb.2025.07.024.
APA：
Liu Yue,Zhou Kai,He Xinlong,Shi Kun,Hu Danrong...&Qian Zhiyong.(2025).A thermo-sensitive hydrogel targeting macrophage reprogramming for sustained osteoarthritis pain relief.Acta Pharmaceutica Sinica B,15,(11)
MLA：
Liu Yue,et al."A thermo-sensitive hydrogel targeting macrophage reprogramming for sustained osteoarthritis pain relief".Acta Pharmaceutica Sinica B 15..11(2025):6034-6051

相关文献

[1]Bulleyaconitine A preferably reduces tetrodotoxin-sensitive sodium current in uninjured dorsal root ganglion neurons of neuropathic rats probably via inhibition of protein kinase C [2]神经钙蛋白在奥沙利铂引起的神经病理性疼痛中的作用 [3]Synergistic Interaction Between Dexmedetomidine and Ulinastatin Against Vincristine-Induced Neuropathic Pain in Rats [4]Mitogen- and stress-activated kinase 1 in primary sensory neurons contributes to formalin-induced tonic pain [5]Managing Pain in Patients With Cancer: The Chinese Good Pain Management Experience [6]Inflammation-Targeted Nanomedicines Alleviate Oxidative Stress and Reprogram Macrophages Polarization for Myocardial Infarction Treatment [7]Long-term effects of acupuncture for chronic prostatitis/chronic pelvic pain syndrome: systematic review and single-arm meta-analyses. [8]Cancer pain management in China: current status and practice implications based on the ACHEON survey [9]恶性肿瘤患者疼痛现状调查研究 [10]四川省55所二级甲等及以上医院癌痛规范化护理的现状分析

资源点击量：65780 今日访问量：0 总访问量：5151 更新日期：2025-12-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 四川省肿瘤医院 技术支持：重庆聚合科技有限公司 地址：成都市人民南路四段55号