Purpose/Objective(s): Spatially fractionated radiation therapy (SFRT) delivers a high dose to certain areas within the gross tumor volume (GTV) and reduces the radiation toxicity to normal tissues. For SFRT based on VMAT, due to the limitations of the machine’s hardware conditions, both PVDR and ADR are at relatively low values. In contrast, PVDR and ADR can reach relatively good values based on Cyberknife. However, when GTV has a relatively large volume, Cyberknife requires a long treatment time making it unsuitable for clinical treatment. Therefore, we have designed a novel planning strategy that uses the Cyberknife to design a high dose for the lattice points and the VMAT to provide low-dose coverage for GTV. This approach can achieve relatively high PVDR and ADR values, and ensure that the treatment time is feasible for clinical treatment.