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Optimizing breast cancer chemotherapy by harnessing gut microbiota with insights from artificial intelligence

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资源类型：
Pubmed体系：
作者：
Zhou Yi[1] * ; Jiang Min[1] ; Shen Ke[1] ; He Tao[1] ; Zhou Siyu[1] ; Shao Aibin[1] ; Li Xiaoyu[1] ; Wang Jiao[1] ; Wu Rongrong[1] ; Singla Rajeev K[1,2] ; Jacobs Jonathan P[3] ; Shen Bairong[1] ;
机构： [1]Department of Breast Surgery and Institute for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, SichuanUniversity, Chengdu, Sichuan, China [2]School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India [3]Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
出处：
DOI： 10.1038/s41522-025-00825-4

摘要：
Optimizing chemotherapy for breast cancer (BC) remains a critical challenge. Gut microbiota (GM) dysbiosis, varying across BC subtypes and stages, influences BC development and chemotherapy response through immune and metabolic pathways. Chemotherapy also disrupts the microbiota, creating a complex bidirectional interaction. Integrating artificial intelligence (AI) allows the identification of hidden patterns, deepening our understanding of the microbiota's role. This integrated approach promises to revolutionize BC treatment with novel insights and personalized interventions.© 2025. The Author(s).

基金：
This work was supported by the National Natural Science Foundation of China (No. 32070671 & No. 32270690). The figures are generated by BioRender.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类 | 1 区 生物学
小类 | 1 区 生物工程与应用微生物 1 区 微生物学
最新[2025]版：
大类 | 1 区 生物学
小类 | 1 区 生物工程与应用微生物 1 区 微生物学
第一作者：
第一作者机构： [1]Department of Breast Surgery and Institute for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, SichuanUniversity, Chengdu, Sichuan, China
通讯作者：
推荐引用方式(GB/T 7714)：
Zhou Yi,Jiang Min,Shen Ke,et al.Optimizing breast cancer chemotherapy by harnessing gut microbiota with insights from artificial intelligence[J].NPJ Biofilms And Microbiomes.2025,11(1):198.doi:10.1038/s41522-025-00825-4.
APA：
Zhou Yi,Jiang Min,Shen Ke,He Tao,Zhou Siyu...&Shen Bairong.(2025).Optimizing breast cancer chemotherapy by harnessing gut microbiota with insights from artificial intelligence.NPJ Biofilms And Microbiomes,11,(1)
MLA：
Zhou Yi,et al."Optimizing breast cancer chemotherapy by harnessing gut microbiota with insights from artificial intelligence".NPJ Biofilms And Microbiomes 11..1(2025):198

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