个人中心| | 帮助
高级检索
当前位置： 首页 > 详情页

Biomaterial-based strategies for cell-free nucleic acids scavenging and macrophage modulation in oral diseases: Mechanisms and therapeutic potential

| 认领 | 导出 | |

文献详情

资源类型：
Pubmed体系：
作者：
Chen Jiali[1,2] * ; Cheng Xu[1,2] * ; Zhang Shiming[1,2] ; Sui Hao[1,2] ; Fang Kun[3] ; Li Shili[4] ; Yang Renjie[1] ; Yang Chao[5] ; Shao Dan[1] ; Zheng Qian[1,2] ; Shi Bing[1,2,*1] ; Leong Kam W[6,7,*2] ; Huang Hanyao[1,2,6,*1] ;
机构： [1]State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, [2]Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, China [3]Institute for Cancer Genetics, Columbia University Irving Medical Center, New York, NY, 10032, USA [4]The Antibody Laboratory, Department of Microbiology, Immunology & Molecular Genetics, UT Health Science Center, San Antonio, TX, 78229, USA [5]Department of Orthopaedics, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, 510630, China [6]Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA [7]Department of Systems Biology, Columbia University Medical Center, New York, NY, 10032, USA
出处：
DOI： 10.1016/j.biomaterials.2025.123773
ISSN：

关键词： Oral diseases Biomaterials Cell-free nucleic acids Macrophage Innate immunity

摘要：
Cell-free nucleic acids (cfNAs), including cfDNA and cfRNA, have emerged as potent drivers of inflammation and immune dysregulation in oral diseases by activating nucleic acid-sensing pathways and inducing macrophage polarization. These processes disrupt immune homeostasis and impair tissue regeneration, positioning cfNAs not only as biomarkers but also as active immunological effectors. Recent advances highlight the therapeutic potential of biomaterial-based strategies for scavenging cfNAs and modulating macrophage phenotypes. These include cationic polymers, nanoparticles, hydrogels, micro/nanogels, nano/microfibers, microneedles, and enzymatic or artificial nuclease systems. This review systematically outlines cfNA-sensing mechanisms and the resulting macrophage-mediated immune responses that drive oral pathologies, and discusses emerging biomaterial platforms designed to restore immune balance and facilitate tissue repair. These insights underscore the translational promise of cfNA-scavenging immunotherapies across a broad spectrum of oral diseases.Copyright © 2025 Elsevier Ltd. All rights reserved.

基金：
This work was supported by the National Natural Science Foundation of China (82301148 and 82470955); China Postdoctoral Science Foundation (2024T170605); Sichuan Province Science and Technology Support Program (2025ZNSFSC0758); Sichuan Postdoctoral Science Foundation (TB2022005); Health Commission of Sichuan Province Medical Science and Technology Program (24QNMP060); Research Funding from West China School/Hospital of Stomatology Sichuan University (RCDWJS2024-7, RCDWJS2025-5); Reseearch and Develop Program, West China Hospital of Stomatology Sichuan University (RD- 02-202511).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类 | 1 区 医学
小类 | 1 区 工程：生物医学 1 区 材料科学：生物材料
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 工程：生物医学 1 区 材料科学：生物材料
第一作者：
第一作者机构： [1]State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, [2]Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, China
共同第一作者：
通讯作者：
通讯机构： [1]State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, [2]Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, China [6]Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA [7]Department of Systems Biology, Columbia University Medical Center, New York, NY, 10032, USA [*1]State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, China [*2]Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA.
推荐引用方式(GB/T 7714)：
Chen Jiali,Cheng Xu,Zhang Shiming,et al.Biomaterial-based strategies for cell-free nucleic acids scavenging and macrophage modulation in oral diseases: Mechanisms and therapeutic potential[J].Biomaterials.2025,327:123773.doi:10.1016/j.biomaterials.2025.123773.
APA：
Chen Jiali,Cheng Xu,Zhang Shiming,Sui Hao,Fang Kun...&Huang Hanyao.(2025).Biomaterial-based strategies for cell-free nucleic acids scavenging and macrophage modulation in oral diseases: Mechanisms and therapeutic potential.Biomaterials,327,
MLA：
Chen Jiali,et al."Biomaterial-based strategies for cell-free nucleic acids scavenging and macrophage modulation in oral diseases: Mechanisms and therapeutic potential".Biomaterials 327.(2025):123773

相关文献

[1]When DNA-damage responses meet innate and adaptive immunity [2]TRIM31: A molecule with a dual role in cancer [3]Oxidative stress, innate immunity, and age-related macular degeneration. [4]The crosstalk between DNA-damage responses and innate immunity [5]Pharmacological activation of estrogen receptor beta augments innate immunity to suppress cancer metastasis. [6]SOCS3 Drives Proteasomal Degradation of TBK1 and Negatively Regulates Antiviral Innate Immunity [7]The role of Semaphorin 3A in oral diseases [8]A decade of progress: bibliometric analysis of trends and hotspots in oral microbiome research (2013-2022) [9]Betrixaban is a broad anti-virus inhibitor by activating innate immunity [10]STING信号通路及其功能

资源点击量：65768 今日访问量：2 总访问量：5150 更新日期：2025-12-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 四川省肿瘤医院 技术支持：重庆聚合科技有限公司 地址：成都市人民南路四段55号