A nitric oxide-releasing organic selenium-grafted phosphorylcholine coating for thrombosis and inflammation prevention in extracorporeal membrane oxygenation
机构：[1]Department of Critical Care Medicine, Institute of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.四川大学华西医院[2]National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610064, China.[3]Department of Respiratory Therapy, West China Hospital, Sichuan University, Chengdu, China.四川大学华西医院[4]College of Materials Science and Engineering, Sichuan University, Chengdu, 610065, China.[5]Institute of Critical Care Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.四川大学华西医院
Thrombosis and inflammation represent major challenges limiting the functionality of asymmetric poly(4-methyl-1-pentene) (PMP) hollow fiber membranes in extracorporeal membrane oxygenation (ECMO) systems. Moreover, the interplay between these two pathological processes can further exacerbate both coagulation and inflammatory responses. In this study, a dual-functional surface modification strategy was developed by first pre-functionalizing PMP hollow fiber membranes with selenocystamine, followed by grafting a phosphorylcholine copolymer MA(PCLA) to form a coating with combined anti-thrombotic and anti-inflammatory properties. Selenocystamine mimics endothelial nitric oxide release to suppress inflammatory responses, while MA(PCLA) mimics the structure of cell membranes to reduce protein adsorption and cellular adhesion. This approach is designed to provide a safer and more effective strategy for mitigating thrombotic and inflammatory complications. In vitro blood circulation assays demonstrated that the modified membranes exhibited significantly reduced protein adsorption, platelet adhesion, and thrombosis compared to both unmodified and commercially modified PMP membranes. Furthermore, both in vitro and in vivo experiments confirmed that the coating effectively modulates inflammatory cell differentiation and attenuates inflammatory responses. The dual-functional coating, exhibiting synergistic anti-thrombotic and anti-inflammatory effects, holds considerable promise for application in blood-contacting medical devices, particularly ECMO systems.
基金：
This study was supported by the funding as following: National
Natural Science Foundation of China [32271398] and
[32371401] and [32401118]; Sichuan Natural Science Foundation Program [2024NSFSC1241] and [2024NSFSC0239]; CAMS
Innovation Fund for Medical Sciences (CIFMS) (No. 2021-12M5-013)]; the Noncommunicable Chronic Diseases – National
Science and Technology Major Project [2023ZD0502400].
语种：
外文
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出版当年[2025]版：
大类|3 区材料科学
小类|3 区材料科学：生物材料
最新[2025]版：
大类|3 区材料科学
小类|3 区材料科学：生物材料
第一作者：
第一作者机构：[1]Department of Critical Care Medicine, Institute of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.
共同第一作者：
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推荐引用方式(GB/T 7714)：
Wang Lietao,Zhang Fanjun,Luo Rifang,et al.A nitric oxide-releasing organic selenium-grafted phosphorylcholine coating for thrombosis and inflammation prevention in extracorporeal membrane oxygenation[J].Journal Of Materials Chemistry. B.2025,doi:10.1039/d5tb01647a.
APA：
Wang Lietao,Zhang Fanjun,Luo Rifang,Fu Xin,Lai Wei...&Wang Yubing.(2025).A nitric oxide-releasing organic selenium-grafted phosphorylcholine coating for thrombosis and inflammation prevention in extracorporeal membrane oxygenation.Journal Of Materials Chemistry. B,,
MLA：
Wang Lietao,et al."A nitric oxide-releasing organic selenium-grafted phosphorylcholine coating for thrombosis and inflammation prevention in extracorporeal membrane oxygenation".Journal Of Materials Chemistry. B .(2025)
