Purpose/Objective(s): Proton-induced radiodynamic therapy (P-RDT) combines the advantages of proton therapy and photodynamic therapy, and which core is to achieve radiodynamic therapy by activating photosensitizers with high-energy protons to produce reactive oxygen (ROS). The "Bragg peak" characteristics of protons can not only reduce the radiation dose to endangered organs, but also achieve targeted activation of photosensitizers in tumor tissues, reduce the toxicity of photosensitizers to normal tissues behind the tumor, and synergistically enhance the protective effect on normal tissues. Traditional photosensitizers are generally organic nanomaterials with poor radiation resistance and are not suitable for highenergy proton irradiation. We hypothesize that PEG-modified Nano ZnO (PEG@ZnO NPs) composites can be used for P-RDT and enhance the biological effects of proton therapy.