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Health utility book: A systematic review and meta-analysis of health utilities in gastric cancer

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收录情况： ◇ SCIE

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机构： [1]Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, ON, Canada [2]Department of Health Research Methods, Evidence, and Impact, McMaster University, CRL 223, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada [3]Evidence‑Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu, China [4]College of Pharmacy, Dalhousie University, Halifax, NS, Canada [5]Department of General Surgery, McMaster University, Hamilton, ON, Canada [6]Department of Science and Technology, Clinical Research Centre, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China [7]Child Health Evaluative Sciences, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada [8]School of Public Health, Fudan University, Shanghai, China [9]School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, Jiangsu, China [10]Department of Medicine, Division of Cardiology, UC Davis, Sacramento, CA, USA [11]Northern California Healthcare System, Mather, CA, USA [12]Centre for Evidence‑Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, Beijing, China [13]School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China [14]Centre for Health Economics and Policy Analysis, McMaster University, CRL 223, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada

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The treatment landscape in gastric cancer has changed drastically over the last 15 years with surgical advancements and the introduction of new therapeutic agents and combinations. Despite the potential for improved survival, these new interventions can impact health-related quality of life (HRQoL). Our objective was to identify and synthesize health utility data for gastric cancer patients as part of the Health Utility Book (HUB) project.We searched MEDLINE, EMBASE, EconLit, and CINAHL from inception to March 2023 for original studies that reported health utility data for gastric cancer. Records were screened independently and in duplicate by two reviewers. Data on study design, patient characteristics, and health utilities were extracted using a standardized form. A random effects meta-analysis was conducted to synthesize health utilities by cancer stage. Heterogeneity was evaluated using the I2 statistic.600 health utilities from 3,405 respondents were identified across 19 studies. All studies were published between 2018 and 2022 and most were conducted in Asia (n = 12, 63.2%). The EQ-5D was the most common method of preference elicitation (n = 17, 89.5%), and health utilities ranged from 0.298 (SD 0.088) to 0.920 (SD 0.130). Mean health utilities from random effects models were 0.82 (95% Confidence Interval [CI] 0.76-0.88), 0.76 (95% CI 0.68-0.85), and 0.67 (95% CI 0.46-0.87) for early stage, advanced stage, and metastatic gastric cancer, respectively.This systematic review provides a reference set of health utilities for gastric cancer, which can help understand HRQoL and facilitate the retrieval and selection of health utilities for economic evaluations.© 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

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出版当年[2025]版：

大类 | 3 区医学

小类 | 2 区康复医学 3 区卫生保健与服务 3 区肿瘤学

最新[2025]版：

大类 | 3 区医学

小类 | 2 区康复医学 3 区卫生保健与服务 3 区肿瘤学

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出版当年[2024]版：

Q1 REHABILITATION Q2 HEALTH CARE SCIENCES & SERVICES Q2 ONCOLOGY

最新[2024]版：

Q1 REHABILITATION Q2 HEALTH CARE SCIENCES & SERVICES Q2 ONCOLOGY

影响因子： 3 最新[2024版] 3.4 最新五年平均 3 出版当年[2024版] 0 出版当年五年平均 3 出版前一年[2024版]

第一作者：

第一作者机构： [1]Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, ON, Canada

通讯作者：

通讯机构： [2]Department of Health Research Methods, Evidence, and Impact, McMaster University, CRL 223, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada [14]Centre for Health Economics and Policy Analysis, McMaster University, CRL 223, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada

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