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Assessment and correction of the respiratory phase misalignment using different signals in 4-dimensional imaging and free-breathing gated radiotherapy

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机构: [1]Beihang Univ, Sch Phys, Beijing 102206, Peoples R China [2]Peking Univ, Dept Radiat Oncol, Key Lab Carcinogenesis & Translat Res, Minist Educ Beijing,Canc Hosp & Inst, Beijing 100142, Peoples R China [3]China Pharmaceut Univ, Sch Int Pharmaceut Business, Nanjing 211198, Peoples R China [4]Peking Univ, Sch Hlth Humanities, Beijing 100191, Peoples R China [5]Cent South Univ, Affiliated Canc Hosp, Hunan Canc Hosp, Xiangya Sch Med, Changsha 410013, Hunan, Peoples R China [6]Hong Kong Polytech Univ, Dept Hlth Technol & Informat, Hong Kong 999077, Peoples R China [7]Peking Univ, State Key Lab Nucl Phys & Technol, Beijing 100871, Peoples R China [8]Univ Elect Sci & Technol China, Sichuan Canc Hosp & Inst, Sichuan Clin Res Ctr Canc,Dept Radiotherapy, Sichuan Canc Ctr,Precis Radiat Oncol Key Lab Sichu, Chengdu 610041, Peoples R China
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关键词: Radiotherapy Respiratory motion Phase shift Diaphragm Optical surface imaging

摘要:
Objective: To propose and validate a correction method for the respiratory phase shift of using different motion management systems in the 4-dimensional (4D) imaging and free-breathing gated radiotherapy. Materials and methods: Synchronized cone-beam CT (CBCT) and optical surface images (OSI) of 30 patients at two institutions were included. Reference diaphragm-signals were extracted from CBCT projections using Amsterdam-Shroud (AS) method. Principal Component Analysis (PCA) was used to reduce the dimensionality of OSI data. The phase shift between the AS and PCA signals was calculated using the cross-correlation function. The 20 patients in public 4D-Lung dataset were used for external validation. The relative phase shift averaged over the dataset was proposed as the correction factor. Based on two signals, 4DCBCT were reconstructed using Feldkamp-Davis-Kress (FDK) algorithm respectively. Results: Phase discrepancies of 396 f 106 ms were observed in the clinical patients. The OSI signals consistently lagged behind the diaphragm signals by 12 % f 3 % (clinical) and 12 % f 6 % (public) of a respiratory cycle. Using 12 % as a correction factor, the phase shift was reduced to 76 ms (by 81 %) on average for the 30 clinical patients, and the Root Mean Square Error was significantly decreased by 10-23 % for the phase-averaged 4DCBCT. For 20 public cases, the tumor centroid displacement was reduced by 1.5 f 0.9 mm, and the intersessional variation was 2 % f 1 % of a respiratory cycle for the 10 cases with multiple 4DCT. Conclusion: The significant phase inconsistency using different motion management techniques should be monitored and corrected before navigating 4D imaging and treatment.

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出版当年[2025]版:
大类 | 2 区 医学
小类 | 2 区 肿瘤学 2 区 核医学
最新[2025]版:
大类 | 2 区 医学
小类 | 2 区 肿瘤学 2 区 核医学
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出版当年[2024]版:
Q1 ONCOLOGY Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2024]版:
Q1 ONCOLOGY Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

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第一作者机构: [1]Beihang Univ, Sch Phys, Beijing 102206, Peoples R China
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