Objective: To propose and validate a correction method for the respiratory phase shift of using different motion management systems in the 4-dimensional (4D) imaging and free-breathing gated radiotherapy. Materials and methods: Synchronized cone-beam CT (CBCT) and optical surface images (OSI) of 30 patients at two institutions were included. Reference diaphragm-signals were extracted from CBCT projections using Amsterdam-Shroud (AS) method. Principal Component Analysis (PCA) was used to reduce the dimensionality of OSI data. The phase shift between the AS and PCA signals was calculated using the cross-correlation function. The 20 patients in public 4D-Lung dataset were used for external validation. The relative phase shift averaged over the dataset was proposed as the correction factor. Based on two signals, 4DCBCT were reconstructed using Feldkamp-Davis-Kress (FDK) algorithm respectively. Results: Phase discrepancies of 396 f 106 ms were observed in the clinical patients. The OSI signals consistently lagged behind the diaphragm signals by 12 % f 3 % (clinical) and 12 % f 6 % (public) of a respiratory cycle. Using 12 % as a correction factor, the phase shift was reduced to 76 ms (by 81 %) on average for the 30 clinical patients, and the Root Mean Square Error was significantly decreased by 10-23 % for the phase-averaged 4DCBCT. For 20 public cases, the tumor centroid displacement was reduced by 1.5 f 0.9 mm, and the intersessional variation was 2 % f 1 % of a respiratory cycle for the 10 cases with multiple 4DCT. Conclusion: The significant phase inconsistency using different motion management techniques should be monitored and corrected before navigating 4D imaging and treatment.
基金:
National Natural Science Foundation of China [12411530076, 12275012, 12475309, 12581360004, 82202941]; Beijing Natural Science Foundation [Z210008]; University Grants Committee, Health and Medical Research Fund [HMRF 10211606]; Health Bureau, Innovation and Technology Support Programme [ITS/049/22FP]; Innovation and Technology Commission, Hong Kong Special Administrative Regions; China International Talent Exchange Foundation [JC202502001F]; Chengdu Science and Technology Project [2024-YF05-02583-SN]; Ministry of Education Exchange Program for Teachers and Students of Higher Education Institutions in the Chinese Mainland/Hong Kong/Macao [7111400072]; National Key R & D Program of China [2019YFF01014405]; Inner Mongolia Science & Technology Project Plan [2022YFSH0064]; General Research Fund; Fundamental Research Funds for the Central Universities/Clinical Medicine Plus X - Young Scholars Project of Peking University [GRF 15104822]; [PKU2025PKULCXQ014]
语种:
外文
WOS:
PubmedID:
中科院(CAS)分区:
出版当年[2025]版:
大类|2 区医学
小类|2 区肿瘤学2 区核医学
最新[2025]版:
大类|2 区医学
小类|2 区肿瘤学2 区核医学
JCR分区:
出版当年[2024]版:
Q1ONCOLOGYQ1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2024]版:
Q1ONCOLOGYQ1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
第一作者机构:[1]Beihang Univ, Sch Phys, Beijing 102206, Peoples R China
共同第一作者:
通讯作者:
推荐引用方式(GB/T 7714):
Chen Lekang,Yu Shutong,Zhao Qicheng,et al.Assessment and correction of the respiratory phase misalignment using different signals in 4-dimensional imaging and free-breathing gated radiotherapy[J].RADIOTHERAPY AND ONCOLOGY.2025,212:doi:10.1016/j.radonc.2025.111116.
APA:
Chen, Lekang,Yu, Shutong,Zhao, Qicheng,Yu, Songmao,Yang, Junqian...&Zhang, Yibao.(2025).Assessment and correction of the respiratory phase misalignment using different signals in 4-dimensional imaging and free-breathing gated radiotherapy.RADIOTHERAPY AND ONCOLOGY,212,
MLA:
Chen, Lekang,et al."Assessment and correction of the respiratory phase misalignment using different signals in 4-dimensional imaging and free-breathing gated radiotherapy".RADIOTHERAPY AND ONCOLOGY 212.(2025)