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Research progress on nanoplatforms based delivery of traditional Chinese medicine against multi-drug resistance in breast cancer

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资源类型：
Pubmed体系：
作者：
Li Gangcui[1,2] * ; Duan Xianghui[1,2] * ; Zhou Yanan[1,2] ; Wang Hong[1,2] ; He Wenlu[1,4] ; Sun Qin[1,2,3] ; Zhao Fulan[2,3] ; Spacil Roman[5] ; Miao Wenjun[1,2,3] ; Ren Wei[1,2,3] ;
机构： [1]National Traditional Chinese Medicine Clinical Research Base and Drug Research Center of Integrated Traditional Chinese and Western Medicine, the Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646000, China [2]Luzhou Key Laboratory of research and development of medical institution preparations and large-scale health products, the Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646000, China [3]Institute of Integrated Chinese and Western Medicine, Southwest Medical University, Luzhou, Sichuan 646000, China [4]Sino-Portugal TCM International Cooperation Center, the Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646000, China [5]The Czech Center for Traditional Chinese Medicine, Jeremenkova 1211/40, Olomouc 77900, Czech Republic
出处：
DOI： 10.1016/j.phymed.2025.157097
ISSN：

关键词： Breast cancer Drug delivery system Multi-drug resistance Nanoplatforms Traditional chinese medicine

摘要：
In the comprehensive clinical management of breast cancer, the emergence of multi-drug resistance often presents substantial challenges to effective drug therapy. Traditional Chinese medicine has shown great potential in reversing multi-drug resistance in breast cancer, but its application is limited due to the poor water-solubility and unsatisfactory targeting.This review summarizes the research progress in the nanoplatforms based delivery of active ingredients from traditional Chinese medicine, highlighting their potential in multimodal synergistic therapy to tackle multi-drug resistance in breast cancer.The review summarizes the recent research progress of nanoplatforms based delivery of traditional Chinese medicine and their combination with photothermal, photodynamic, immune and other therapies towards multi-drug resistance in breast cancer.This review analyzes the multi-drug resistance mechanisms in breast cancer and classifies the encapsulated active ingredients from traditional Chinese medicine. Further, the multimodal strategies for combining traditional Chinese medicine with photothermal, photodynamic, and immune synergistic therapy are updated.The review reveals that nanoplatform-based delivery of traditional Chinese medicine can enhance biocompatibility and targeting while mitigating systemic toxicity. And their combination with photothermal, photodynamic and immune therapeutics makes it more efficient to kill cancer cells, eliminate breast tumors, and enhance drug efficacy, finally tackling the limitations of traditional Chinese medicine towards multi-drug resistance in breast cancer.This review highlights the therapeutic advantages of nanoplatforms for delivering traditional Chinese medicine to tackle multi-drug resistance in breast cancer and provides new strategies for their further clinical applications.Copyright © 2025 Elsevier GmbH. All rights reserved.

基金：
the Sichuan Science and Technology Program (Grant No. 2024NSFSC1818), the National Natural Science Foundation of China (Grant No. 82304908) and the National Advantageous Specialized Construction Unit of Traditional Chinese Medicine for Clinical Pharmacy ([2024]90).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类 | 1 区 医学
小类 | 1 区 药物化学 1 区 全科医学与补充医学 1 区 药学 1 区 植物科学
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 药物化学 1 区 全科医学与补充医学 1 区 药学 1 区 植物科学
第一作者：
第一作者机构： [1]National Traditional Chinese Medicine Clinical Research Base and Drug Research Center of Integrated Traditional Chinese and Western Medicine, the Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646000, China [2]Luzhou Key Laboratory of research and development of medical institution preparations and large-scale health products, the Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646000, China
共同第一作者：
通讯作者：
通讯机构： [1]National Traditional Chinese Medicine Clinical Research Base and Drug Research Center of Integrated Traditional Chinese and Western Medicine, the Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646000, China [2]Luzhou Key Laboratory of research and development of medical institution preparations and large-scale health products, the Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646000, China [3]Institute of Integrated Chinese and Western Medicine, Southwest Medical University, Luzhou, Sichuan 646000, China
推荐引用方式(GB/T 7714)：
Li Gangcui,Duan Xianghui,Zhou Yanan,et al.Research progress on nanoplatforms based delivery of traditional Chinese medicine against multi-drug resistance in breast cancer[J].Phytomedicine : International Journal Of Phytotherapy And Phytopharmacology.2025,146:157097.doi:10.1016/j.phymed.2025.157097.
APA：
Li Gangcui,Duan Xianghui,Zhou Yanan,Wang Hong,He Wenlu...&Ren Wei.(2025).Research progress on nanoplatforms based delivery of traditional Chinese medicine against multi-drug resistance in breast cancer.Phytomedicine : International Journal Of Phytotherapy And Phytopharmacology,146,
MLA：
Li Gangcui,et al."Research progress on nanoplatforms based delivery of traditional Chinese medicine against multi-drug resistance in breast cancer".Phytomedicine : International Journal Of Phytotherapy And Phytopharmacology 146.(2025):157097

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